(phenylmethylene-iminomethyl)-dimethyl-phosphine oxide | 276694-40-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (phenylmethylene-iminomethyl)-dimethyl-phosphine oxide
• 英文别名: N-(dimethylphosphorylmethyl)-1-phenylmethanimine
• CAS: 276694-40-7
• 化学式: C₁₀H₁₄NOP
• 分子量: 195.201
• InChiKey: KXRDQSTVGKZPOM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-甲基苄溴 、 (phenylmethylene-iminomethyl)-dimethyl-phosphine oxide 在 lithium diisopropyl amide 作用下， 生成
  参考文献：
  名称：

  Maier, Ludwig, Phosphorus, Sulfur and Silicon and the Related Elements, 1990, vol. 53, # 1-4, p. 43 - 67

  摘要：

  DOI：
• 作为产物：
  描述：

  二甲基磷酰甲胺 、 苯甲醛 以 苯 为溶剂， 反应 4.0h， 以92%的产率得到(phenylmethylene-iminomethyl)-dimethyl-phosphine oxide
  参考文献：
  名称：

  SCHIFF BASES DERIVED FROM AMINOMETHYL-DIMETHYL-PHOSPHINE OXIDE

  摘要：

  A group of Schiff bases 1 - 18 derived from aminomethyl-dimethyl-phosphine oxide with aromatic aldehydes have been synthesized. Structure and purity of the new compounds were determined by IR, H-1 NMR and P-31(H-1) NMR spectroscopy, mass spectrometry and elemental analysis.

  DOI：

  10.1080/10426500008043655

文献信息

• Synthesis of Dimethylphosphinyl-substituted α-Amino(aryl)methylphosphonic Acids and Their Esters
  作者：Yulian Zagraniarsky、Bojidarka Ivanova、Karamfil Nikolov、Sabi Varbanov、Tsvetanka Cholakova

  DOI：10.1515/znb-2008-1009

  日期：2008.10.1

  Dimethylphosphinylmethylamine (1) and its aldimines 2 were used for the preparation of dimethyl and diethyl α-amino(aryl)methylphosphonates 3a - l via imine hydrophosphonylation and Kabachnik-Fields reaction. Their acid hydrolysis gave rise to the corresponding α-aminophosphonic acids 4a - e. Compounds 3 and 4 have two different phosphorus-containing groups - phosphonyl and dimethylphosphinyl - and might have interesting biological activity.

  通过亚胺水解磷化和Kabachnik-Fields反应，利用二甲基膦基甲胺（1）及其醛亚胺2制备了二甲基和二乙基α-氨基（芳基）甲基膦酸酯3a-l。它们的酸水解反应形成了相应的α-氨基膦酸4a-e。化合物3和4具有两种不同的含磷基团-膦酰基和二甲基膦基甲基-可能具有有趣的生物活性。

• Synthesis of Dimethylphosphinoyl Substituted α-Aminoarylmethanephosphonates
  作者：Tsvetanka Cholakova、Yulian Zagraniarsky、Gerhard Hägele、Tania Tosheva、Bojidarka Ivanova、Rosario Scopelliti、Sabi Varbanov

  DOI：10.1515/znb-2005-0215

  日期：2005.2.1

  New dimethylphosphinoyl-substituted α-aminoarylmethanephosphonates 1a - f have been synthesized via addition of dimethyl or diethyl phosphites to Schiff bases and via Kabachnik-Fields reaction. The structure of the compounds was confirmed by elemental analysis, IR, ¹H and ³¹P¹H} NMR spectroscopy, mass spectrometry and in two cases by X-ray diffraction.

  新的二甲基磷酰基取代的α-氨基芳基甲基膦酸酯1a-f已通过向席夫碱和Kabachnik-Fields反应物中加入二甲基或二乙基磷酸酯合成。该化合物的结构已通过元素分析、红外光谱、1H和31P1H} NMR光谱、质谱和两种情况下的X射线衍射证实。