| 688024-95-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• CAS: 688024-95-5
• 化学式: C₅₃H₅₇N₅O₈
• 分子量: 892.064
• InChiKey: BVXYTOJPYVMOBI-QLKFWGTOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  9.41
• 重原子数：
  66.0
• 可旋转键数：
  18.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  158.99
• 氢给体数：
  3.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  在 二乙胺 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta

  摘要：

  The synthesis and biochemical characterization of AX4697, a fluorescent, bisindolylmaleimide-derived probe for PKC alpha and beta, is described. AX4697 was able to quantify changes in PKC expression in drug-treated Jurkat cells and was shown to covalently label PKC alpha on C619, a residue that sits just outside the active site. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.045
• 作为产物：
  描述：

  3-[1-(6-Hydroxyhexyl)indol-3-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione 、 N-alpha-芴甲氧羰基-N-epsilon-叔丁氧羰基-L-赖氨酸 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.75h， 生成
  参考文献：
  名称：

  Design and synthesis of AX4697, a bisindolylmaleimide exo-affinity probe that labels protein kinase C alpha and beta

  摘要：

  The synthesis and biochemical characterization of AX4697, a fluorescent, bisindolylmaleimide-derived probe for PKC alpha and beta, is described. AX4697 was able to quantify changes in PKC expression in drug-treated Jurkat cells and was shown to covalently label PKC alpha on C619, a residue that sits just outside the active site. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.08.045