[PtCl2(ofloxacin)] | 1161829-26-0

• 英文名称: [PtCl2(ofloxacin)]
• CAS: 1161829-26-0；1162693-99-3
• 化学式: C₁₈H₂₀Cl₂FN₃O₄Pt
• 分子量: 627.359
• InChiKey: DHGJFTAVUYLYSP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  potassium tetrachloroplatinate(II) 、 氧氟沙星 以 水 为溶剂， 以71.9%的产率得到[PtCl2(ofloxacin)]
  参考文献：
  名称：

  Platinum(II) complexes with fluoroquinolones: Synthesis and characterization of unusual metal–piperazine chelates

  摘要：

  The fluoroquinolones constitute an important class of synthetic antimicrobial agents. The interaction between these compounds and metallic cations has been investigated primarily with the goal of identifying the functional groups directly linked to the metal. Furthermore, there has been some additional work investigating the effect of metal ions upon antibacterial activity. The vast majority of the metallic complexes reported in the literature show coordination of the fluoroquinolone through the carboxylate and the carbonyl oxygen atoms. In this work, we report the synthesis and characterization of platinum(II) complexes with ciprofloxacin, levofloxacin, ofloxacin, sparfloxacin, and gatifloxacin. The resulting complexes present the fluoroquinolone coordinated through the nitrogen atoms of the piperazine ring, which is unusual. The proposed structures were supported by spectroscopic evidence (IR, NMR, and mass spectra) as well as by theoretical studies. (C) 2008 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2008.08.018