2-(Furan-2-yl)-6-thiophen-3-ylpyridine | 1030918-02-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(Furan-2-yl)-6-thiophen-3-ylpyridine
• CAS: 1030918-02-5
• 化学式: C₁₃H₉NOS
• 分子量: 227.287
• InChiKey: ZZEDEIWKWMXVSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  54.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3-二甲基氨基-1-(3-噻吩)-1-丙酮 、 1-(2-furan-2-yl-2-oxo-ethyl)-pyridinium iodide 在 乙酸铵 作用下， 以 乙醇 为溶剂， 反应 18.0h， 生成 2-(Furan-2-yl)-6-thiophen-3-ylpyridine
  参考文献：
  名称：

  Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities

  摘要：

  For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities. (c) 2007 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2007.05.002

文献信息

• Synthesis of 2,6-diaryl-substituted pyridines and their antitumor activities
  作者：Jong-Keun Son、Long-Xuan Zhao、Arjun Basnet、Pritam Thapa、Radha Karki、Younghwa Na、Yurngdong Jahng、Tae Cheon Jeong、Byeong-Seon Jeong、Chong-Soon Lee、Eung-Seok Lee

  DOI：10.1016/j.ejmech.2007.05.002

  日期：2008.4

  For the development of novel antitumor agents, we designed and synthesized 2,6-diaryl-substituted pyridine derivatives bearing three aryl groups, which are the bioisosteres of terpyridine, and evaluated their biological activities. Most of the 18 prepared compounds showed moderate cytotoxicity against several human cancer cell lines. From the structure-activity relationships we may conclude that the number of aryl groups employed would be critical for their biological activities. (c) 2007 Elsevier Masson SAS. All rights reserved.