3-(2-(2-chlorophenyl)-6-(furan-2-yl)pyridin-4-yl)phenol | 1375113-16-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-(2-(2-chlorophenyl)-6-(furan-2-yl)pyridin-4-yl)phenol
• 英文别名: 3-[2-(2-Chlorophenyl)-6-(furan-2-yl)pyridin-4-yl]phenol
• CAS: 1375113-16-8
• 化学式: C₂₁H₁₄ClNO₂
• 分子量: 347.801
• InChiKey: KSCWXMDSXGEOEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间羟基苯甲醛 在 ammonium acetate 、 溶剂黄146 、 sodium hydroxide 作用下， 以 乙醇 、 水 为溶剂， 反应 24.0h， 生成 3-(2-(2-chlorophenyl)-6-(furan-2-yl)pyridin-4-yl)phenol
  参考文献：
  名称：

  Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety

  摘要：

  We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and 11 inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase 1 inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.03.010