4-hydroxy-1-phenyl-3-phenylacetyl-quinolin-2(1H)-one | 161185-51-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-hydroxy-1-phenyl-3-phenylacetyl-quinolin-2(1H)-one
• 英文别名: 4-hydroxy-1-phenyl-3-(2-phenylacetyl)quinolin-2-one
• CAS: 161185-51-9
• 化学式: C₂₃H₁₇NO₃
• 分子量: 355.393
• InChiKey: BUWYQFQHDAEUSP-UHFFFAOYSA-N

物化性质

• 沸点：
  570.4±50.0 °C(Predicted)
• 密度：
  1.334±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  57.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-hydroxy-1-phenyl-3-phenylacetyl-quinolin-2(1H)-one 在 肼 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以70%的产率得到3-benzyl-5-phenyl-1H-pyrazolo[4,3-c]quinolin-4(5H)-one
  参考文献：
  名称：

  HETEROCYCLIC COMPOUND, AND PRODUCTION PROCESS AND USE THEREOF

  摘要：

  公开号：

  EP1925617B1
• 作为产物：
  描述：

  2H-吡喃并[3,2-c]喹啉-2,5(6H)-二酮,4-羟基-3,6-二苯基- 在 sodium hydroxide 作用下， 以 乙二醇 为溶剂， 反应 1.5h， 以77%的产率得到4-hydroxy-1-phenyl-3-phenylacetyl-quinolin-2(1H)-one
  参考文献：
  名称：

  Syntheses of 3-Acyl-4-hydroxy-2(1H)quinolones

  摘要：

  3-Acyl-4-hydroxy-2(1H)-quinolones 5 are obtained by hydrolytic ring opening and subsequent decarboxylation from the corresponding pyrano[3,2-c]quinolin-2,5(6H)-diones 4, which in turn are easily obtained from 1:2 condensation of anilines 1 with diethyl malonate 2a or 1:1 condensation of diethyl alkyl- or arylmalonates 2b-e with 4-hydroxy-2(1H)-quinolones 3. Nitropyranoquinolinediones 6 furnish after ringopening 3-nitroacetyl-4-hydroxy-2(1H)quinolones 8. Pyranoquinolines 7 and 9 with acetyl- or aminosubstituents are hydrolyzed during basic ringopening to yield 5.

  DOI：

  10.1002/prac.19943360707

文献信息

• Heterocycle compound, and production process and application thereof
  申请人：Aska Pharmaceutical Co., Ltd.

  公开号：US08193356B2

  公开（公告）日：2012-06-05

  The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.

  本发明的化合物是一种具有特定杂环骨架的新型化合物，特别是具有通过3位的烷基与5位的碳环键合的有机基团（例如，碳环和杂环）的吡唑啉萘或吡唑喹啉骨架，并具有磷酸二酯酶IV抑制活性。在吡唑啉萘骨架的3位和5位的碳环键合中，至少一个环（碳环或杂环）可能具有卤代烷基和/或卤代烷氧基作为取代基。这样的化合物或其盐对于磷酸二酯酶IV抑制剂等具有用途。根据本发明，可以提供一种具有高磷酸二酯酶IV抑制效果的新型化合物。
• Heterocycle Compound, and Production Process and Application Thereof
  申请人：Kanazawa Hashime

  公开号：US20090131467A1

  公开（公告）日：2009-05-21

  The compound of the present invention is a novel compound which has a specific heterocycle skeleton, particularly a pyrazolonaphthyridine or pyrazoloquinoline skeleton having an organic group (e.g., a carbocycle and a heterocycle) bonding through an alkylene group at 3-position and a carbocycle bonding at 5-position and has a phosphodiesterase IV inhibitory activity. At least one of the ring (the carbocycle or the heterocycle) bonding at 3-position of the pyrazolonaphthyridine skeleton and the carbocycle bonding at 5-position may have a halogenated alkyl group and/or a halogenated alkoxy group as a substituent. Such a compound or a salt thereof is useful as a phosphodiesterase IV inhibitor and the like. According to the present invention, a novel compound having a high phosphodiesterase IV inhibitory effect can be provided.

  本发明的化合物是一种新型化合物，具有特定的杂环骨架，特别是具有通过3位的烷基与5位的碳环键合的有机基团（例如，碳环和杂环）的吡唑萘啶或吡唑喹啉骨架，并具有磷酸二酯酶IV抑制活性。在吡唑萘啶骨架的3位键合的环（碳环或杂环）和5位键合的碳环中，至少有一个可以具有卤代烷基和/或卤代烷氧基作为取代基。这种化合物或其盐可用作磷酸二酯酶IV抑制剂等。根据本发明，可以提供一种具有高磷酸二酯酶IV抑制效果的新型化合物。
• US8193356B2
  申请人：——

  公开号：US8193356B2

  公开（公告）日：2012-06-05