cis-5'-O-[4-(pyrid-3-yl)-2-oxo-1,2,3-dioxaphosphorin-2-yl]-2'-C-methylcytidine | 926654-97-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: cis-5'-O-[4-(pyrid-3-yl)-2-oxo-1,2,3-dioxaphosphorin-2-yl]-2'-C-methylcytidine
• 英文别名: 4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-3-methyl-5-[(2-oxo-4-pyridin-3-yl-1,3,2lambda5-dioxaphosphinan-2-yl)oxymethyl]oxolan-2-yl]pyrimidin-2-one；4-amino-1-[(2R,3R,4R,5R)-3,4-dihydroxy-3-methyl-5-[(2-oxo-4-pyridin-3-yl-1,3,2λ5-dioxaphosphinan-2-yl)oxymethyl]oxolan-2-yl]pyrimidin-2-one
• CAS: 926654-97-9
• 化学式: C₁₈H₂₃N₄O₈P
• 分子量: 454.376
• InChiKey: KIWPWPAREWOSHO-QWSWVQMBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  166
• 氢给体数：
  3
• 氢受体数：
  9

文献信息

• Novel 2'-c-methyl and 4'c-methyl nucleoside derivatives
  申请人：Erion Mark D.

  公开号：US20090118223A1

  公开（公告）日：2009-05-07

  Novel 2′-C-methyl nucleoside 5′-monophosphate and 4′-C-methyl nucleoside 5′-monophosphate derivatives, stereoisomers, and pharmaceutically acceptable salts or prodrugs thereof, their preparation, and their uses for the treatment of hepatitis C viral infection are described.