E7Qbh2W4Z4 | 1844861-19-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: E7Qbh2W4Z4
• 英文别名: 6-chloro-5-fluoro-1-(2-fluoroethyl)-2-[5-(imidazol-1-ylmethyl)pyridin-3-yl]benzimidazole
• CAS: 1844861-19-3
• 化学式: C₁₈H₁₄ClF₂N₅
• 分子量: 373.8
• InChiKey: WXVNUTHBSLNKBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  48.5
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：EP3162802A1

  公开（公告）日：2017-05-03

  Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. (In the formula, R1 represents a hydrogen atom or CO2Ra; R2 represents a hydrogen atom, a halogen atom, or CO2Ra; R3 represents a hydrogen atom or a C1-10 hydroxyalkyl group; R4 represents a hydrogen atom, a hydroxy group, or a C1-10 alkoxy group; R5 represents a C1-5 chain alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C3-5 cyclic alkyl group in which the hydrogen atoms are optionally substituted with halogen atoms, a C1-5 hydroxyalkyl group, or an o-, p-, or m-halobenzyl group; A represents CH or a nitrogen atom; X1 and X3 independently represent hydrogen atoms or halogen atoms; X2 represents a hydrogen atom, a halogen atom, or a nitrile group; at least one of X1, X2, and X3 represents a halogen atom; and Ra independently represents a C1-10 alkyl group.)

  本发明提供了通式（1）代表的化合物或其盐，以及含有该化合物或该盐的药物。(式中，R1 代表氢原子或 CO2Ra；R2 代表氢原子、卤素原子或 CO2Ra；R3 代表氢原子或 C1-10 羟烷基；R4 代表氢原子、羟基或 C1-10 烷氧基；R5 代表氢原子任选被卤素原子取代的 C1-5 链烷基、氢原子任选被卤素原子取代的 C3-5 环烷基、C1-5 羟烷基或邻、对、间苄基；A代表CH或氮原子；X1和X3独立地代表氢原子或卤素原子；X2代表氢原子、卤素原子或腈基；X1、X2和X3中至少有一个代表卤素原子；Ra独立地代表C1-10烷基。)
• NON-INVASIVE DIAGNOSTIC IMAGING AGENT FOR HEART DISEASE
  申请人：Nihon Medi-Physics Co., Ltd.

  公开号：EP3470091A1

  公开（公告）日：2019-04-17

  The present invention addresses the problem of providing a technique for detecting a lesion of a heart disease in a non-invasive manner. The present invention provides a non-invasive diagnostic imaging agent for a heart disease, which contains a radioactively labeled compound capable of binding to an aldosterone synthase or a salt thereof as an active ingredient.

  本发明要解决的问题是提供一种以非侵入方式检测心脏病病变的技术。本发明提供了一种心脏疾病的非侵入性诊断成像剂，它含有能与醛固酮合成酶结合的放射性标记化合物或其盐作为活性成分。
• 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicine containing same
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：US10189815B2

  公开（公告）日：2019-01-29

  Provided is a compound represented by general formula (1) or a salt thereof as well as a medicine containing the compound or the salt. In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined.

  本文提供了通式（1）代表的化合物或其盐，以及含有该化合物或其盐的药物。 式中，R1、R2、R3、R4、R5、X1、X2 和 X3 的定义如下。
• 2-(3-pyridinyl)-1H-benzimidazole derivative compound and medicament containing same
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：US10358434B2

  公开（公告）日：2019-07-23

  Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R1, R2, R3, R4, R5, X1, X2, and X3 are defined. Methods for producing various radioactive compounds are also provided.

  本发明提供了一种药物，该药物由以下通式（1）所代表的化合物或其盐组成： 式中，R1、R2、R3、R4、R5、X1、X2 和 X3 已定义。此外，还提供了生产各种放射性化合物的方法。
• 2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICAMENT CONTAINING SAME
  申请人：NIHON MEDI-PHYSICS CO., LTD.

  公开号：US20190169169A1

  公开（公告）日：2019-06-06

  Provided is a medicament comprising the compound represented by the following general formula (1) or a salt thereof: In the formula, R 1 , R 2 , R 3 , R 4 , R 5 , X 1 , X 2 , and X 3 are defined. Methods for producing various radioactive compounds are also provided.