3-[(1Z,4Z,9Z,15Z)-8-(1-Hydroxy-ethyl)-18-(2-methoxycarbonyl-ethyl)-3,7,12,17-tetramethyl-13-vinyl-porphyrin-2-yl]-propionic acid methyl ester | 10589-91-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 3-[(1Z,4Z,9Z,15Z)-8-(1-Hydroxy-ethyl)-18-(2-methoxycarbonyl-ethyl)-3,7,12,17-tetramethyl-13-vinyl-porphyrin-2-yl]-propionic acid methyl ester
• CAS: 10589-91-0
• 化学式: C₃₆H₄₀N₄O₅
• 分子量: 608.737
• InChiKey: WTMGOKOKNXMXBH-IJWWJSAYSA-N

反应信息

• 作为反应物：
  描述：

  3-[(1Z,4Z,9Z,15Z)-8-(1-Hydroxy-ethyl)-18-(2-methoxycarbonyl-ethyl)-3,7,12,17-tetramethyl-13-vinyl-porphyrin-2-yl]-propionic acid methyl ester 、 3-[(4Z,10Z,15Z,19Z)-7-Acetyl-12-(1-bromo-ethyl)-18-(2-methoxycarbonyl-ethyl)-3,8,13,17-tetramethyl-22,24-dihydro-porphin-2-yl]-propionic acid methyl ester 生成
  参考文献：
  名称：

  Syntheses, stability, and tumorcidal activity of porphyrin dimers and trimers with ether linkages

  摘要：

  The first syntheses of a series of regiochemically pure porphyrin dimers and trimers with ether linkages which are structurally related to Photofrin-II(R) are described. Stability of these oligomers was investigated using variable temperature proton NMR spectroscopy, and preliminary biological results reveal that manupulation of peripheral substituents causes a remarkable difference in photosensitizing ability in vivo.

  DOI：

  10.1016/s0040-4039(00)88499-3