4-[1-羟基-2-(4-羟基苯基)丙-2-基]苯酚 | 142648-65-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[1-羟基-2-(4-羟基苯基)丙-2-基]苯酚
• 中文别名: (R)-3-氨基缬草酸乙基酯
• 英文名称: 2,2-Bis(4-hydroxyphenyl)-1-propanol
• 英文别名: 4-[1-hydroxy-2-(4-hydroxyphenyl)propan-2-yl]phenol
• CAS: 142648-65-5
• 化学式: C₁₅H₁₆O₃
• 分子量: 244.28
• InChiKey: HHOUSCIEKLBSGQ-UHFFFAOYSA-N

物化性质

• 溶解度：
  可溶于乙酸乙酯（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  双酚A 、 氢(+1)阳离子 、 NADH 、 氧气 生成 4-[1-羟基-2-(4-羟基苯基)丙-2-基]苯酚 、 水 、 nicotinamide adenine dinucleotide
  参考文献：
  名称：

  Spivack J.; Leib T.K.; Lobos J.H., J Biol Chem, 1994, 0021-9258, 7323-9

  摘要：

  DOI：

文献信息

• 2,2-Bis(4-hydroxyphenyl)-alkyl onium salt and process for the preparation thereof
  申请人：Mallikarjuna Shroff Rama

  公开号：US20070191606A1

  公开（公告）日：2007-08-16

  The present invention provides novel 2,2-bis(4-hydroxyphenyl)-alkyl onium salts as illustrated by 2,2-bis(4-hydroxyphenyl)-tridecyl(1,2-dimethylimidazolium)bromide and a process for preparation thereof by hydroxyalkylating acetoacetate to the corresponding hyroxyalkylacetoacetate, dealkoxycarbonylating the hydroxyalkyl acetoacetate to ω-hydroxyalkan-2-one and contacting the ω-hydroxyalkan-2-one with phenol in the presence of an acidic catalyst to give 2,2-bis(4-hydroxyphenyl)alkanol, brominating the 2,2-bis(4-hydroxyphenyl)alkanol to 2,2-bis(4-hydroxyphenyl)alkyl bromide, quaternizing 1,2-dimethylimidazole with the 2,2-bis(4-hydroxyphenyl)alkyl bromide to 2,2-bis(4-hydroxyphenyl)alkyl(1,2-dimethylimidazolium)bromide. The products can be used as reactive modifiers for layered phyllosilicates that can be used in the preparation of polymer-nanocomposites, wherein the said polymers are prepared from 2,2-bis(4-hydroxyphenyl)propane as one of the reacting monomers.

  本发明提供了新型的2,2-双(4-羟基苯基)-烷基季铵盐，如2,2-双(4-羟基苯基)-十三烷基(1,2-二甲基咪唑)溴化物，并提供了一种制备该盐的方法，通过将乙酰乙酸酯羟基烷基化为相应的羟基烷基乙酰乙酸酯，脱去烷氧羰基化合物的羟基烷基乙酰乙酸酯为ω-羟基烷基-2-酮，并在酸性催化剂存在下将ω-羟基烷基-2-酮与苯酚接触，得到2,2-双(4-羟基苯基)烷醇，溴化2,2-双(4-羟基苯基)烷醇为2,2-双(4-羟基苯基)烷基溴化物，将1,2-二甲基咪唑与2,2-双(4-羟基苯基)烷基溴化物季铵化为2,2-双(4-羟基苯基)烷基(1,2-二甲基咪唑)溴化物。这些产品可用作层状硅酸盐的反应改性剂，可用于制备聚合物-纳米复合材料，其中所述聚合物是由2,2-双(4-羟基苯基)丙烷作为反应单体之一制备的。
• Reactive polyvinyl chloride and polymer products made therefrom
  申请人：THE B.F. GOODRICH COMPANY

  公开号：EP0371216A2

  公开（公告）日：1990-06-06

  Thermoplastic polymers exhibiting improved physical properties and a method for preparing same are described. The method of preparing these polymer compositions comprises reacting a functionalized base polymer composition having pendant cyclic anhydride groups with a coreactive second moiety. Said functionalized base polymer comprises the reaction product of: I. a hydroxyl containing base polymer comprising the reaction product of: a) a vinyl halide monomer; and b) at least one other ethylenically unsaturated monomer having at least one pendant hydroxyl functional group; and II. a cyclic polyanhydride functionalizing agent.

  本发明描述了具有更好物理性能的热塑性聚合物及其制备方法。制备这些聚合物组合物的方法包括使具有下垂环酸酐基团的官能化基础聚合物组合物与具有芯活性的第二分子发生反应。所述官能化基础聚合物包括以下反应产物： I. 含羟基的基质聚合物，包括以下物质的反应产物 a) 卤化乙烯基单体；和 b) 至少一种具有至少一个悬垂羟基官能团的其他乙烯基不饱和单体；和 II. 环状聚酸酐官能化剂。
• Transvinylation process for the preparation of thermally labile vinyl compounds and vinyl compounds prepared from thermally labile acids
  申请人：UNION CARBIDE CHEMICALS & PLASTICS TECHNOLOGY CORPORATION

  公开号：EP0506070A2

  公开（公告）日：1992-09-30

  There is described an improved process for the preparation of thermally labile vinyl compounds and for the preparation of vinyl compounds from thermally labile Bronsted acids which comprises reacting a vinyl derivative of a first Bronsted acid with a thermally labile Bronsted acid in the presence of a ruthenium compound at a temperature at which transvinylation occurs and recovering as a product of transvinylation the vinyl derivative of the thermally labile acid. The vinyl product derivative itself may, or may not, be thermally labile depending on the vinyl derivative of the Bronsted acid.

  本发明描述了一种用于制备热敏性乙烯基化合物和从热敏性布郎斯特德酸制备乙烯基化合物的改进工艺，该工艺包括在钌化合物存在下，在发生乙烯基化的温度下，使第一种布郎斯特德酸的乙烯基衍生物与热敏性布郎斯特德酸反应，并作为乙烯基化产物回收热敏性布郎斯特德酸的乙烯基衍生物。乙烯基产物衍生物本身可能是热敏性的，也可能不是，这取决于布郎斯特酸的乙烯基衍生物。
• Dental composition
  申请人：DENTSPLY DETREY GmbH

  公开号：EP2963025A1

  公开（公告）日：2016-01-06

  Dental composition comprising (a) one or more di- or polyepoxides having 2 to 5 epoxide groups and having a molecular weight of from 200 to 700 Da, or a macromonomeric reaction product obtainable by reacting the diepoxide with a dicarboxylic acid in a molar ratio [diepoxide]/[dicarboxylic acid] of at least 2; (b) one or more primary monoamines and/or disecondary diamines; (c) optionally one or more aliphatic polyamines; (d) a particulate filler, wherein the molar ratio of epoxide groups in component (a) to the N-H bonds in component (b) and (c) [epoxide(a)]/[N-H(b),(c)] is in the range of from 0.9 to 1.1; wherein the di- or polyepoxide having 2 to 5 epoxide groups is a compound of the following formula (I):          A(BZm)n     (I) wherein A represents an n-valent organic moiety optionally having 1 to 10 heteroatoms selected from oxygen atoms and sulfur atoms; and B represents an m+1-valent organic moiety, Z is an epoxide group which may have a substituent, m which are independent from each other represent an integer of at least 1; and n is an integer of from 1 to 5; wherein the m are selected so that 2 to 5 epoxide groups are present; wherein the composition does not contain any 2,2-bis-(4-hydroxyphenyl)-propane, or 2,2-bis-(4-hydroxyphenyl)-methane.

  牙科组合物，包括 (a) 一种或多种具有 2 至 5 个环氧基团且分子量为 200 至 700 Da 的二环氧化物 或多环氧化物，或通过二环氧化物与二羧酸反应得到的大单体反应产物， 其摩尔比[二环氧化物]/[二羧酸]至少为 2； (b) 一种或多种伯胺和/或二元二胺； (c) 可选的一种或多种脂肪族多胺； (d) 微粒填料、 其中，组分（a）中环氧化物基团与组分（b）和（c）中 N-H 键的摩尔比[环氧化物（a）]/[N-H（b），（c）]在 0.9 至 1.1 之间； 其中具有 2 至 5 个环氧化物基团的二环氧化物或多环氧化物是下式 (I) 的化合物： A(BZm)n (I) 其中 A 代表 n 价有机分子，可选择具有 1 至 10 个杂原子，这些杂原子选自氧原子和硫原子；以及 B 代表 m+1 价有机分子、 Z 是环氧基团，可具有取代基、 m 代表至少 1 的整数；以及 n 是 1 至 5 的整数； 其中 m 的选择使环氧基团的数量为 2 至 5 个； 其中组合物不含任何 2,2-双-(4-羟基苯基)-丙烷或 2,2-双-(4-羟基苯基)-甲烷。
• Stabilizer and coating compositions thereof
  申请人：SWIMC LLC

  公开号：US10316211B2

  公开（公告）日：2019-06-11

  Coating compositions that include a thermoplastic dispersion and an epoxy-functional stabilizer having polyhydric phenols that exhibit estrogenic activity less than bisphenol S.

  涂料组合物，其中包括热塑性分散体和环氧功能稳定剂，环氧功能稳定剂中的多羟基酚的雌激素活性低于双酚 S。