(Benzoyl-benzyloxy-amino)-acetic acid | 161146-37-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Benzoyl-benzyloxy-amino)-acetic acid
• 英文别名: 2-[benzoyl(phenylmethoxy)amino]acetic acid
• CAS: 161146-37-8
• 化学式: C₁₆H₁₅NO₄
• 分子量: 285.299
• InChiKey: HVVDWSCDLIYTJM-UHFFFAOYSA-N

物化性质

• 沸点：
  523.3±43.0 °C(Predicted)
• 密度：
  1.279±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (Benzoyl-benzyloxy-amino)-acetic acid 在 苯甲醚 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 38.0h， 生成 (6R,7R)-3-Acetoxymethyl-7-[2-(benzoyl-benzyloxy-amino)-acetylamino]-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid
  参考文献：
  名称：

  New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity

  摘要：

  The synthesis and the antimicrobial properties of a new series of cephalosporinic beta-lactam antibiotics is described. The data reported in the present paper show the potential of this type of substituted cephalosporins as new anti Gram-positive antibiotic drugs. In fact, all compounds tested showed a good in vitro antibacterial activity against the most relevant Gram-positive pathogens including resistant species that currently represent unmet medical need. On the contrary, the new synthesized compounds were found to be completely devoid of any activity on Gram-negative bacteria up to a concentration of the single agent of 128 mu g/ml. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(99)00127-4
• 作为产物：
  描述：

  2-((苄氧基)亚氨基)乙酸 在 盐酸 、 氢氧化钾 、 三乙胺-硼烷 作用下， 以 1,4-二氧六环 、 乙醇 、 水 为溶剂， 反应 6.0h， 生成 (Benzoyl-benzyloxy-amino)-acetic acid
  参考文献：
  名称：

  Synthesis and aldose reductase inhibitory activity of N-(arylsulfonyl)- and N-(aroyl)-N-(arylmethyloxy)glycines

  摘要：

  Some N-(arylsulfonyl)- C and N-(aroyl)-N-(arylmethyloxy)glycines D were synthesised and tested as aldose reductase inhibitors (ARIs). They are structurally related to the previously described ARIs of type A and B, from which they differ owing to the presence of a spacer, an OCH2 group, between the amino-acid nitrogen and the aromatic ring. The inhibitory activity was evaluated on the bovine lens aldose reductase enzyme. Compounds of types C and D show an inhibitory activity which, in the case of compounds D, is very similar to that reported for the parent compounds B. Kinetic studies carried out on the most active compound (8a), reveal that it produces an inhibition which, depending on its concentration, may be either uncompetitive or noncompetitive with respect to the substrate and the cofactor.

  DOI：

  10.1016/0223-5234(94)90138-4