5-(propen-1-yl)uracil | 134218-79-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(propen-1-yl)uracil
• 英文别名: 5-[(Z)-prop-1-enyl]-1H-pyrimidine-2,4-dione
• CAS: 134218-79-4
• 化学式: C₇H₈N₂O₂
• 分子量: 152.153
• InChiKey: PPTBYVVCEZHLQZ-IHWYPQMZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• Nucleoside 5'-alkyl- or alkenylphosphate
  申请人：Yamasa Shoyu Kabushiki Kaisha

  公开号：EP0097376A1

  公开（公告）日：1984-01-04

  Nucleoside 5'-alkyl- or alkenyl phosphate compounds represented by the following formula [I] wherein B is a purine base having a substituent or a 5-substituted uracil base, and R' is an alkyl or alkenyl group having 14 to 26 carbon atoms, and pharmaceutically acceptable salts thereof are novel derivatives of arabinonucleosides which can have properties suitable for clinical application as antiviral agents, particularly for treating viral hepatitis.

  由下式[I]代表的核苷 5'-烷基-或烯基磷酸酯化合物 其中 B 是具有取代基的嘌呤基或 5-取代的尿嘧啶基，R'是具有 14 至 26 个碳原子的烷基或烯基，及其药学上可接受的盐是阿拉伯核苷的新型衍生物，其特性适合作为抗病毒药物，特别是用于治疗病毒性肝炎的临床应用。
• Phospholepid derivatives of nucleosides as antitumaorl medicaments
  申请人：Herrmann Dieter

  公开号：US20050090659A1

  公开（公告）日：2005-04-28

  The present invention relates to drugs containing phospholipid derivatives preferably of non-natural nucleosides corresponding to general formula I: in which R 1 represents an alkyl chain with 10-14 carbon atoms, R 2 represents an alkyl chain with 8-12 carbon atoms, n represents an integer equal to 0 to 2, R 3 represents a hydroxy group, R 4 and R 5 represent hydrogen, and B represents 5-fluorouracil, for use as antitumoral or antiproliferative active ingredients for the prophylaxis and/or curative, palliative or supportive treatment of tumor diseases or neoplasias, such as for example carcinomas, sarcomas, lymphomas or leukemias, both as therapeutic or prophylactic agents for monotherapy and in free or fixed combination with other modalities of prophylaxis or therapy.

  本发明涉及含有磷脂衍生物的药物，最好是通式 I 所对应的非天然核苷的磷脂衍生物： 其中 R 1 代表含有 10-14 个碳原子的烷基链、 R 2 代表具有 8-12 个碳原子的烷基链，n 代表等于 0-2 的整数、 R 3 代表羟基、 R 4 和 R 5 代表氢，B 代表 5-氟尿嘧啶，用作抗肿瘤或抗增生活性成分，用于预防和/或治疗、缓解或支持性治疗肿瘤疾病或肿瘤，例如癌、肉瘤、淋巴瘤或白血病，既可作为治疗剂或预防剂用于单一疗法，也可与其他预防或治疗方式自由或固定组合使用。
• EP0135587A4
  申请人：——

  公开号：EP0135587A4

  公开（公告）日：1986-04-02
• DEFINED SEQUENCE SINGLE STRAND OLIGONUCLEOTIDES INCORPORATING REPORTER GROUPS, PROCESS FOR THE CHEMICAL SYNTHESIS THEREOF, AND NUCLEOSIDES USEFUL IN SUCH SYNTHESIS
  申请人：SYNGENE, INC.

  公开号：EP0135587B1

  公开（公告）日：1990-05-02
• PHOSPHOLIPID-DERIVATE VON NUCLEOSIDEN ALS ANTITUMORALE ARZNEIMITTEL
  申请人：Heidelberg Pharma Holding GmbH

  公开号：EP1448579A1

  公开（公告）日：2004-08-25