4-[2-(2-氟苯基)乙烯]-N,N-二甲基苯胺 | 959-73-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 4-[2-(2-氟苯基)乙烯]-N,N-二甲基苯胺
• 英文名称: 2'-Fluoro-4-dimethylaminostilbene
• 英文别名: 4-[2-(2-fluorophenyl)ethenyl]-N,N-dimethylaniline
• CAS: 959-73-9
• 化学式: C₁₆H₁₆FN
• 分子量: 241.308
• InChiKey: CJPYZTZXCORKJE-UHFFFAOYSA-N

物化性质

• 密度：
  1.0918 (estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2921420090

反应信息

• 作为反应物：
  描述：

  4-[2-(2-氟苯基)乙烯]-N,N-二甲基苯胺 在 potassium sulfide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以95%的产率得到4-(benzo[b]thiophen-2-yl)-N,N-dimethylaniline
  参考文献：
  名称：

  Transition-Metal-Free Method for the Synthesis of Benzo[b]thiophenes from o-Halovinylbenzenes and K2S via Direct SNAr-Type Reaction, Cyclization, and Dehydrogenation Process

  摘要：

  A new, highly efficient procedure for the synthesis of benzothiophenes from easily available o-halovinylbenzenes and potassium sulfide has been developed. The reaction tolerated a wide range of functionalities, and various 2-substituted benzo[b]thiophenes are provided in the high yields in the absence of a transition-metal catalyst.

  DOI：

  10.1055/s-0033-1339289
• 作为产物：
  描述：

  2-氟溴苄 在 potassium tert-butylate 作用下， 以 四氢呋喃 、 甲苯 为溶剂， 反应 11.0h， 生成 4-[2-(2-氟苯基)乙烯]-N,N-二甲基苯胺
  参考文献：
  名称：

  Transition-Metal-Free Method for the Synthesis of Benzo[b]thiophenes from o-Halovinylbenzenes and K2S via Direct SNAr-Type Reaction, Cyclization, and Dehydrogenation Process

  摘要：

  A new, highly efficient procedure for the synthesis of benzothiophenes from easily available o-halovinylbenzenes and potassium sulfide has been developed. The reaction tolerated a wide range of functionalities, and various 2-substituted benzo[b]thiophenes are provided in the high yields in the absence of a transition-metal catalyst.

  DOI：

  10.1055/s-0033-1339289

文献信息

• Transition-Metal-Free Method for the Synthesis of Benzo[b]thiophenes from o-Halovinylbenzenes and K2S via Direct SNAr-Type Reaction, Cyclization, and Dehydrogenation Process
  作者：Yun Liang、Xiaoyun Zhang、Weilan Zeng、Yuan Yang、Hui Huang

  DOI：10.1055/s-0033-1339289

  日期：——

  A new, highly efficient procedure for the synthesis of benzothiophenes from easily available o-halovinylbenzenes and potassium sulfide has been developed. The reaction tolerated a wide range of functionalities, and various 2-substituted benzo[b]thiophenes are provided in the high yields in the absence of a transition-metal catalyst.