(S)-[N-3-(4-(2-(4-pivaloylpiperazin-1-yl)pyrimidin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide | 380380-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (S)-[N-3-(4-(2-(4-pivaloylpiperazin-1-yl)pyrimidin-5-yl)-3-fluorophenyl)-2-oxo-5-oxazolidinyl]methyl acetamide
• 英文别名: N-[[(5S)-3-[4-[2-[4-(2,2-dimethylpropanoyl)piperazin-1-yl]pyrimidin-5-yl]-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
• CAS: 380380-96-1
• 化学式: C₂₅H₃₁FN₆O₄
• 分子量: 498.557
• InChiKey: LQWGUKWDNSPGNQ-IBGZPJMESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Novel oxazolidinone derivatives and a process for the preparation thereof
  申请人：——

  公开号：US20030166620A1

  公开（公告）日：2003-09-04

  The present invention relates to novel oxazolidinone derivatives, their pharmaceutically acceptable salts and a process for the preparation thereof. More particularly, the present invention relates to oxazolidinone derivatives having pyridine or pyrimidine moeity substituted by heterocycle and heteroaromaticcycle at 4-position of phenyl ring. The compounds of the present invention have wide antibacterial spectrum, superior antibacterial activity and low toxicity, such that the compound of this invention can be used as an antibacterial agent.

  本发明涉及新颖的噁唑烷酮衍生物，其药用盐以及其制备方法。更具体地，本发明涉及在苯环的4位被杂环和杂芳环取代的噁唑烷酮衍生物。本发明的化合物具有广泛的抗菌谱、优越的抗菌活性和低毒性，因此本发明的化合物可用作抗菌剂。
• US6689779B2
  申请人：——

  公开号：US6689779B2

  公开（公告）日：2004-02-10