6-methyl-5-heptene-1-tosylate | 84717-43-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 6-methyl-5-heptene-1-tosylate
• 英文别名: 6-methyl-5-heptenyl tosylate；6-methylhept-5-enyl 4-methylbenzenesulfonate
• CAS: 84717-43-1
• 化学式: C₁₅H₂₂O₃S
• 分子量: 282.404
• InChiKey: HYFYQJVSQKDTSY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-methyl-5-heptene-1-tosylate 生成 1-溴-6-甲基-5-庚烯
  参考文献：
  名称：

  OHNO, KIYOTAKA;NAGASE, HIROSHI;ISHIKAWA, MAMORU;MATSUMOTO, KARUHISA;NISHI+

  摘要：

  DOI：
• 作为产物：
  描述：

  6-methylhept-5-en-1-ol 、 对甲苯磺酰氯 生成 6-methyl-5-heptene-1-tosylate
  参考文献：
  名称：

  OHNO, KIYOTAKA;NAGASE, HIROSHI;ISHIKAWA, MAMORU;MATSUMOTO, KARUHISA;NISHI+

  摘要：

  DOI：

文献信息

• 5,6,7,-Trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives and
  申请人：Toray Industries, Inc.

  公开号：US04564620A1

  公开（公告）日：1986-01-14

  Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-13,14-didehydro PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17-.alpha.-methyl-20-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-17,18,19,20-tetranor-16-phenoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-20-isopropylidene PGI.sub.2, 5,6,7-trinor-4,8-inter-(5-methyl-1,3-phenylene) PGI.sub.2, and 5,6,7-trinor-4,8-inter-m-phenylene-2,3-didehydro-16,17,18,19,20-pentanor-1 5-phenyl PGI.sub.2. They are useful in treatment of ulcers, thrombii and hypertension for example.

  药用化合物是5,6,7-三缺一-4,8-相间-间苯二酚 PGI.sub.2 衍生物，例如 5,6,7-三缺一-4,8-相间-间苯二酚-13,14-二去氢 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-16,16-二甲基 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-17-.alpha.-甲基-20-同源 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-17,18,19,20-四缺一-16-苯氧基 PGI.sub.2，5,6,7-三缺一-4,8-相间-间苯二酚-20-异丙亚甲基 PGI.sub.2，5,6,7-三缺一-4,8-相间-(5-甲基-1,3-苯基) PGI.sub.2，和 5,6,7-三缺一-4,8-相间-间苯二酚-2,3-二去氢-16,17,18,19,20-五缺一 5-苯基 PGI.sub.2。它们在治疗溃疡、血栓和高血压等方面具有用途。
• 5,6,7,-trinor-4,8-inter-m-phenylene 2-nor PGI.sub.2 derivatives and
  申请人：Toray Industries, Inc.

  公开号：US04822804A1

  公开（公告）日：1989-04-18

  Pharmaceutically useful compounds are 5,6,7-trinor-4,8-inter-m-phenylene PGI.sub.2 derivatives such as 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-16,16-dimethyl-.omega.-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(S)-methyl-.omega.-homo PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2-nor-17(R)-methyl-.omega.-homo PGI.sub.2, 5,6, 7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16-p ropoxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-et ho xy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,18,19,20-tetranor-16,16-dimethyl-17-pr op oxy PGI.sub.2, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-phenoxy PGI.sub.2 and methyl esters thereof. 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16,16-dimethyl-16 -phenoxy PGI.sub.2 or its methyl ester, 5,6,7-trinor-4,8-inter-m-phenylene-2,17,18,19,20-pentanor-16-methyl-16-phe nox y PGI.sub.2 or its methyl ester. They are useful in treatment of ulcers, thrombii and hypertension for example.

  药用化合物是5,6,7-三去氢-4,8-间-m-苯撑PGI.sub.2衍生物，如5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-16,16-二甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(S)-甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(R)-甲基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-16,16-二甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(S)-甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2-去氢-17(R)-甲基-ω-同系PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16,16-二甲基-16-丙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,18,19,20-四去氢-16,16-二甲基-17-乙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,18,19,20-四去氢-16,16-二甲基-17-丙氧基PGI.sub.2，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16-苯氧基PGI.sub.2及其甲酯。5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16,16-二甲基-16-苯氧基PGI.sub.2或其甲酯，5,6,7-三去氢-4,8-间-m-苯撑-2,17,18,19,20-五去氢-16-甲基-16-苯氧基PGI.sub.2或其甲酯。它们可用于治疗溃疡、血栓和高血压等疾病。
• On the 6- exo - trig ring closure of substituted 5-hexen-1-oxyl radicals
  作者：Jens Hartung、Thomas Gottwald

  DOI：10.1016/j.tetlet.2004.05.131

  日期：2004.7

  Substituted 5-hexen-1-oxyl radicals have been generated from N-(5-hexen-1-oxy)-5-(p-methoxyphenyl)-4-methylthiazole-2(3H)-thiones under tin-free conditions and have been successfully applied as reactive intermediates in a mechanistic study on the formation of bromomethyl-substituted tetrahydropyrans via 6-exo-trig selective cyclizations.

  在无锡​​条件下，由N-（5-己烯-1-氧基）-5-（对甲氧基苯基）-4-甲基噻唑-2（3 H）-硫酮生成了取代的5-己烯-1-氧基已经在溴甲基取代的四氢吡喃的形成的机理研究经由6-已成功地应用于作为反应中间体外切- trig的选择性环化反应。
• A total synthesis of spirocyclic alkaloids via an intramolecular SN2′ lactam enolate alkylation
  作者：Deukjoon Kim、Hak Sung Kim、Jung Yeol Yoo

  DOI：10.1016/s0040-4039(00)74276-6

  日期：1991.3

  The spirocyclic alkaloid, isonitramine 2 has been synthesized in a highly stereoselective manner by intramolecular S(N)2' lactam enolate alkylation route.
• OHNO, KIYOTAKA;NAGASE, HIROSHI;ISHIKAWA, MAMORU;MATSUMOTO, KARUHISA;NISHI+
  作者：OHNO, KIYOTAKA、NAGASE, HIROSHI、ISHIKAWA, MAMORU、MATSUMOTO, KARUHISA、NISHI+

  DOI：——

  日期：——