N-benzyloxycarbonyl-N-(n-butyl)glycine | 118988-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyloxycarbonyl-N-(n-butyl)glycine
• 英文别名: Glycine, N-butyl-N-[(phenylmethoxy)carbonyl]-；2-[butyl(phenylmethoxycarbonyl)amino]acetic acid
• CAS: 118988-08-2
• 化学式: C₁₄H₁₉NO₄
• 分子量: 265.309
• InChiKey: RTZFKQORWVHODG-UHFFFAOYSA-N

物化性质

• 沸点：
  419.3±34.0 °C(Predicted)
• 密度：
  1.170±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  66.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-benzyloxycarbonyl-N-(n-butyl)glycine 在 palladium on activated charcoal 4-二甲氨基吡啶 、 氢气 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 生成 ethyl 2-[2-[2-[2-[[2-[[3-amino-5-[butyl-[2-[2-[2-[2-(2-ethoxy-2-oxoethoxy)ethoxy]ethoxy]ethylamino]-2-oxoethyl]carbamoyl]benzoyl]-butylamino]acetyl]amino]ethoxy]ethoxy]ethoxy]acetate
  参考文献：
  名称：

  The “chundle” approach to molecular channels synthesis of a macrocycle-based molecular bundle

  摘要：

  DOI：

  10.1016/s0040-4039(00)82119-x
• 作为产物：
  描述：

  N-butylglycine hydrochloride 、 氯甲酸苄酯 在 sodium hydroxide 、 盐酸 作用下， 以 水 、 甲苯 为溶剂， 反应 4.0h， 以66%的产率得到N-benzyloxycarbonyl-N-(n-butyl)glycine
  参考文献：
  名称：

  Polypeptoids from N-Substituted Glycine N-Carboxyanhydrides: Hydrophilic, Hydrophobic, and Amphiphilic Polymers with Poisson Distribution

  摘要：

  Preparation of defined and functional polymers has been one of the hottest topics in polymer science and drug delivery in the recent decade. Also, research on (bio)degradable polymers gains more and more interest, in particular at the interface of these two disciplines. However, in the majority of cases, combination of definition, functionality and degradability, is problematic. Here we present the preparation and characterization (MALDI-ToF MS, NMR, GPC) of nonionic hydrophilic, hydrophobic, and amphiphilic N-substituted polyglycines (polypeptoids), which are expected to be main-chain degradable and are able to disperse a hydrophobic model compound in aqueous media. Polymerization kinetics suggest that the polymerization is well controlled with strictly linear pseudo first-order kinetic plots to high monomer consumption. Moreover, molar mass distributions of products are Poisson-type and molar mass can be controlled by the monomer to initiator ratio. The presented polymer platform is nonionic, backbone degradable, and synthetically highly flexible and may therefore be valuable for a broad range of applications, in particular as a biomaterial.

  DOI：

  10.1021/ma201015y

文献信息

• METHODS FOR PRODUCING CYCLIC COMPOUNDS COMPRISING N-SUBSTITUTED AMINO ACID RESIDUES
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：US20220411462A1

  公开（公告）日：2022-12-29

  The present invention provides methods for producing peptide compounds. The inventors have found that a cyclic peptide compound can be produced efficiently by linking the N-terminal amino acid residue and the C-terminal amino acid residue of a peptide compound in a solvent containing one or more selected from the group consisting of water-immiscible solvents, water-soluble alkyl nitriles, and water-soluble ethers.

  本发明提供了生产肽化合物的方法。发明人发现，在含有水不相溶溶剂、水溶性烷基硝基化合物和水溶性醚类化合物中，通过将肽化合物的N-末端氨基酸残基和C-末端氨基酸残基连接起来，可以高效地生产环肽化合物。
• JULLIEN, LUDOVIC;LEHN, JEAN-MARIE, TETRAHEDRON LETT., 29,(1988) N 31, C. 3803-3806
  作者：JULLIEN, LUDOVIC、LEHN, JEAN-MARIE

  DOI：——

  日期：——