4-[2-羟基-3-[(1-甲基乙基)氨基]丙氧基]-2,3,6-三甲基-苯酚1-乙酸酯盐酸盐(1:1)

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚酯
• 中文名称: 4-[2-羟基-3-[(1-甲基乙基)氨基]丙氧基]-2,3,6-三甲基-苯酚1-乙酸酯盐酸盐(1:1)
• 中文别名: 4-[2-羟基-3-[(1-甲基乙基)氨基]丙氧基]-2,3,6-三甲基-苯酚 1-乙酸酯盐酸盐(1:1)
• 英文名称: hydron;[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate;chloride
• 化学式: C17H28ClNO4
• 分子量: 345.9
• InChiKey: BLWNYSZZZWQCKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  23
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  67.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Purine compounds and methods of use thereof
  申请人：Salzman L. Andrew

  公开号：US20070238694A1

  公开（公告）日：2007-10-11

  The invention relates to Purine Compounds; compositions comprising an effective amount of a Purine Compound; and methods for reducing a subject's rate of metabolism or protecting a subject's heart against myocardial damage during cardioplegia; or for treating or preventing a cardiovascular disease, a neurological disorder, an ischemic condition, a reperfusion injury, obesity, a wasting disease, diabetes, a cellular proliferative disorder, a skin disorder, a radiation-induced injury, a wound or an inflammatory disease comprising administering an effective amount of a Purine Compound to a subject in need thereof.

  这项发明涉及嘌呤化合物；包含有效量嘌呤化合物的组合物；以及用于减少受试者代谢率或在心脏停搏期间保护受试者心脏免受心肌损伤，或用于治疗或预防心血管疾病、神经系统紊乱、缺血情况、再灌注损伤、肥胖、消耗性疾病、糖尿病、细胞增殖紊乱、皮肤疾病、辐射诱导损伤、创伤或炎症疾病的方法，包括向需要的受试者施用有效量的嘌呤化合物。
• COMPOSITIONS AND METHODS FOR PRESERVING PLATELET FUNCTION
  申请人：BIOVEC TRANSFUSION, LLC

  公开号：US20150056604A1

  公开（公告）日：2015-02-26

  Compositions and methods for maintaining platelet functionality and extending the shelf-life of platelets are described. Platelet preservation compositions include a photosensitizer and a plurality of platelet preservation agents. A method for preserving platelets and extending their shelf-life includes irradiating a platelet mixture containing a photosensitizer under conditions sufficient to activate the photosensitizer and inactivate microbes in the platelet mixture to form a microbe-depleted platelet preparation. A plurality of platelet preservation agents are added to the microbe-depleted platelet preparation for extending the platelet shelf-life. Prior to transfusion, the photosensitizer and platelet preservation agents can be removed by diafiltration and/or the use of compound adsorption devices.

  本文描述了维持血小板功能和延长血小板货架寿命的组合物和方法。血小板保存组合物包括光敏剂和多种血小板保存剂。一种保存血小板并延长其货架寿命的方法包括在足以激活光敏剂并灭活血小板混合物中的微生物的条件下，照射含有光敏剂的血小板混合物，以形成去除微生物的血小板制备物。在延长血小板货架寿命之前，向去除微生物的血小板制备物中添加多种血小板保存剂。在输血之前，可以通过透析和/或使用化合物吸附装置去除光敏剂和血小板保存剂。
• Human EPO mimentic hinge core mimetibodies, compositions, methods and uses
  申请人：Centocor Ortho Biotech Inc.

  公开号：EP2123675A2

  公开（公告）日：2009-11-25

  The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

  本发明涉及至少一种新型人EPO拟铰链核心拟态抗体或特定部分或变体，包括编码至少一种EPO拟铰链核心拟态抗体或特定部分或变体的分离核酸、EPO拟铰链核心拟态抗体或特定部分或变体、载体、宿主细胞、转基因动物或植物及其制造和使用方法，包括治疗组合物、方法和装置。
• Anti-IL-23 antibodies, compositions, methods and uses
  申请人：Janssen Biotech, Inc.

  公开号：EP2452694A1

  公开（公告）日：2012-05-16

  An anti-IL-23p19 antibody, including isolated nucleic acids that encode at least one anti-IL-23p19 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  抗IL-23p19抗体，包括编码至少一种抗IL-23p19抗体的分离核酸、载体、宿主细胞、转基因动物或植物，及其制造和使用方法可应用于诊断和/或治疗组合物、方法和装置。
• Anti-IL-6 antibodies, compositions, methods and uses
  申请人：Janssen Biotech, Inc.

  公开号：EP2842968A1

  公开（公告）日：2015-03-04

  An anti-IL-6 antibody, including isolated nucleic acids that encode at least one anti-IL-6 antibody, vectors, host cells, transgenic animals or plants, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.

  抗IL-6抗体，包括编码至少一种抗IL-6抗体的分离核酸、载体、宿主细胞、转基因动物或植物，及其制造和使用方法可应用于诊断和/或治疗组合物、方法和设备中。