2-Methyl-5-(5-methylfuran-2-yl)aniline | 1248024-55-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Methyl-5-(5-methylfuran-2-yl)aniline
• CAS: 1248024-55-6
• 化学式: C₁₂H₁₃NO
• mdl: MFCD14623734
• 分子量: 187.24
• InChiKey: HKJNDMKMESONOK-UHFFFAOYSA-N

物化性质

• 沸点：
  319.2±30.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  39.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  溴乙酸乙酯 、 2-Methyl-5-(5-methylfuran-2-yl)aniline 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 生成 ethyl (2-methyl-5-(5-methylfuran-2-yl)phenyl)glycinate
  参考文献：
  名称：

  WO2024133499A1

  摘要：

  公开号：
• 作为产物：
  描述：

  5-溴-2-甲基苯胺 、 2-甲基呋喃-5-硼酸频哪醇酯 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 以75.3 %的产率得到2-Methyl-5-(5-methylfuran-2-yl)aniline
  参考文献：
  名称：

  WO2024133499A1

  摘要：

  公开号：

文献信息

• [EN] TOLUIDINE SULFONAMIDES AND THEIR USE AS-INHIBITORS<br/>[FR] TOLUIDINE SULFONAMIDES ET LEUR UTILISATION EN TANT QU'INHIBITEURS
  申请人：EUROPEAN MOLECULAR BIOLOGY LAB EMBL

  公开号：WO2010076034A1

  公开（公告）日：2010-07-08

  The present invention provides compounds of formula (I), wherein R1 is a monocyclic 5- or 6-membered heteroaryl; R4 is phenyl or monocyclic 5- or 6-membered heteroaryl; and the other substituents as defined in the claims, that inhibit cell proliferation and cell division and that inhibit the activation of Hypoxia Inducible Factor (HIF)--mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders.
• [EN] TOLUIDINE SULFONAMIDES AND THEIR USE AS HIF-INHIBITORS<br/>[FR] TOLUIDINE SULFONAMIDES ET LEUR UTILISATION EN TANT QU'INHIBITEURS DU FACTEUR HIF
  申请人：EUROPEAN MOLECULAR BIOLOGY LAB EMBL

  公开号：WO2010085968A1

  公开（公告）日：2010-08-05

  The present invention provides compounds of formula (I) wherein R1 is a monocyclic 5- or 6 membered heteroaryl; R4 is a monocyclic 5- or 6 membered heteroaryl and the other substituents as defined in the claims, that inhibit cell proliferation and cell divison and that inhibit the activation of Hypoxia Inductible Factor (HIF)--mediated transcription and signaling under hypoxic conditions. In one aspect, the compounds of the present invention are useful for the preparation of a medicament for the treatment or prevention of a disease or disorder selected from the group consisting of an inflammatory disease, a hyperproliferative disease or disorder, a hypoxia-related pathology and a disease characterized by excessive vascularisation. Also provided is a pharmaceutical composition, comprising a compound of the invention and a second therapeutic agent or radiation, useful for the treatment or prevention of the mentioned diseases or disorders.