N-ethylethylendiamine 4-methyl-phenylsulfonate | 90747-78-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-ethylethylendiamine 4-methyl-phenylsulfonate
• 英文别名: N-ethyl-1,2-diaminoethane mono-p-toluenesulfonate；N'-ethylethane-1,2-diamine;4-methylbenzenesulfonic acid
• CAS: 90747-78-7
• 化学式: C₄H₁₂N₂*C₇H₈O₃S
• 分子量: 260.357
• InChiKey: MCSAZWSCVMKEFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  101
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-吡啶丙腈 、 N-ethylethylendiamine 4-methyl-phenylsulfonate 在 sodium ethanolate 作用下， 以 乙醇 为溶剂， 以60%的产率得到4-[2-(1-ethyl-4,5-dihydro-imidazol-2-yl)ethyl]-pyridine
  参考文献：
  名称：

  Penicillanic acid derivatives

  摘要：

  其中一个氨基团的氮原子是异环戊二烯环的氨基丙酸衍生物，该异环戊二烯环的侧链含有一个未取代的异环戊二烯环，其中含有2到3个氮原子，可用作抗生素。

  公开号：

  US04431653A1

文献信息

• Imidazole derivatives
  申请人：Hoffmann-La Roche Inc.

  公开号：US04537969A1

  公开（公告）日：1985-08-27

  6-Amidinopenicillanic acid derivatives wherein one of the nitrogen atoms of the amidino group is part of a heterocyclic ring having on a side chain an unsubstituted heterocyclic ring containing 2 to 3 nitrogen atoms, and being useful as an antibiotic.

  6-氨基甲酰青霉烷酸衍生物，其中氨基基团的一个氮原子是杂环环中的一部分，在侧链上具有一个含有2至3个氮原子的未取代杂环环，可用作抗生素。
• Novel penicillanic acid derivatives
  申请人：F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft

  公开号：EP0148283A1

  公开（公告）日：1985-07-17

  @ 6-Amidinopenicillanic acid derivatives wherein one of the nitrogen atoms of the amidino group is part of a heterocyclic ring having on a side chain an unsubstituted heterocyclic ring containing 2 to 3 nitrogen atoms, with formula: wherein n is 0 or 1; is a saturated 5 to 7 membered heterocyclic ring containing the nitrogen atom as the only heteroatom, said ring being unsubstituted or substituted in one or more positions with lower alkyl; is a 5 to 7 membered heterocyclic ring having at most one additional nitrogen atom, from 0 to 2 additional double bonds, and, aside from R, either being unsubstituted or substituted in one or more positions with lower alkyl; R is lower alkyl, nitro, hydrogen,-COOH,-(CH2)y-NHR4;-(CH2)y-OR3 and R3 is hydrogen or lower alkyl, y is an integer from 0 to 4; R, is hydrogen, lower alkyl or an amino-protecting group, (Continuation next page) R5 and R6 are hydrogen or lower alkyl and R7 is lower alkylene, hydrolyzable esters thereof, salts thereof and hydrates thereof, and with formula: wherein n is an integer from 0 to 1; R, is hydrogen or lower alkyl; is a saturated 5 to 7 membered heterocyclic ring containing the nitrogen atom as the only heteroatom, said ring being unsubstituted or substituted in one or more positions with lower alkyl; is a 5 to 7 membered heterocyclic ring containing no additional double bonds or can be additionally aromatic when it is 5 membered, said ring being either unsubstituted or substituted in one or more positions with lower alkyl; and R7 is lower alkylene, hydrolyzable esters thereof, salts thereof and hydrates thereof. These compounds are useful as antibiotics.

  @ 6-脒基青霉烷酸衍生物，其中脒基的一个氮原子是一个杂环的一部分，该杂环的侧链上有一个包含 2 至 3 个氮原子的未取代杂环，其式为 其中 n 为 0 或 1； 是含有氮原子作为唯一杂原子的 5 至 7 个成员的饱和杂环，所述环未经取代或在一个或多个位置被低级烷基取代； R是低级烷基、硝基、氢、-COOH、-(CH2)y-NHR4;-(CH2)y-OR3 和-(CH2)y-OR4。 R3 是氢或低级烷基，y 是 0 至 4 的整数；R, 是氢、低级烷基或氨基保护基团， （下页接下页） R5 和 R6 是氢或低级烷基，R7 是低级亚烷基，其可水解酯、其盐和其水合物，并具有 式： 其中 n 是 0 至 1 的整数；R, 是氢或低级烷基； 是含有氮原子作为唯一杂原子的 5 至 7 个成员的饱和杂环，所述环未被取代或在一个或多个位置被低级烷基取代； R7 是低级亚烷基、其可水解酯、其盐类和其水合物。 这些化合物可用作抗生素。
• Copolymer having amino group and process for production thereof
  申请人：DAI-ICHI KOGYO SEIYAKU Co., Ltd.

  公开号：EP0558047A2

  公开（公告）日：1993-09-01

  There are disclosed a copolymer having a secondary amino group such as an alkylpiperazino group or having a formamide group which is introduced via imide group in the side chains of various high polymers and a process for producing the above copolymer by reacting a starting copolymer having the repeating unit originating from an acid anhydride (e.g. maleic anhydride) with a salt of a specific amine (e.g. piperazine derivative) in the presence or absence of a formyl group-containing compound (e.g. formamide) to imidize the starting copolymer and further removing the acid with a base, or by imidizing the starting copolymer with the reaction product between the specific amine and the formyl group-containing compound. The above copolymer is usable for high molecular amino reagents, raw materials for functional high polymers, raw materials for additives, compatibilizers for polymers, resin dyeing improvers, epoxy resin curing agent, resin modifiers, etc.

  本发明公开了一种具有烷基哌嗪基等仲氨基或具有甲酰胺基的共聚物，该共聚物通过酰亚胺基引入到各种高聚物的侧链中，并公开了一种生产上述共聚物的工艺，该工艺是将具有源自酸酐（如马来酸酐）的重复单元的起始共聚物与特定胺盐（如哌嗪衍生物）在存在或不存在含甲酰基化合物（如甲酰胺）的情况下进行反应，使其酰亚胺化，从而生产出上述共聚物。马来酸酐）与特定胺（如哌嗪衍生物）的盐在含甲酰基化合物（如甲酰胺）存在或不存在的情况下进行反应，使起始共聚物酰亚胺化，并用碱进一步除去酸，或用特定胺与含甲酰基化合物的反应产物使起始共聚物酰亚胺化。上述共聚物可用于高分子氨基试剂、功能性高聚物原料、添加剂原料、聚合物相容剂、树脂染色改良剂、环氧树脂固化剂、树脂改性剂等。
• Melloni; Banzatti; Heidempergher, Il Farmaco, 1991, vol. 46, # 9, p. 1011 - 1029
  作者：Melloni、Banzatti、Heidempergher、Marazzi、Ricciardi、Vaghi、Varasi

  DOI：——

  日期：——
• US4431653A
  申请人：——

  公开号：US4431653A

  公开（公告）日：1984-02-14