(S)-methyl 3,3-diphenyl-2-propylaminocarbonyloxybutanoate | 1349685-27-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-methyl 3,3-diphenyl-2-propylaminocarbonyloxybutanoate
• 英文别名: methyl (2S)-3,3-diphenyl-2-(propylcarbamoyloxy)butanoate
• CAS: 1349685-27-3
• 化学式: C₂₁H₂₅NO₄
• 分子量: 355.434
• InChiKey: NKHQSOFWRCJLQH-GOSISDBHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异氰酸丙酯 、 (+/-)-methyl 2-hydroxy-3,3-diphenylbutanoate 在 [Cu((S,S)-((CH3)3CCHCH2OCN)2C(CH3)2)](CF3SO3)2 作用下， 以 二氯甲烷 为溶剂， 反应 12.17h， 以48%的产率得到(R)-methyl 2-hydroxy-3,3-diphenylbutanoate
  参考文献：
  名称：

  Kinetic Resolution of Racemic α-tert-Alkyl-α-hydroxy Esters by Enantiomer-Selective Carbamoylation

  摘要：

  Kinetic resolution of sterically hindered racemic alpha-tert-alkyl-alpha-hydroxy esters is performed by enantiomer-selective carbamoylation with the t-Bu-Box-Cu(II) catalyst (Box = bis(oxazoline)). The reaction with 0.5 equiv of n-C3H7NCO is carried out with a substrate-to-catalyst molar ratio of 500-5000 at -20 to 25 degrees C. The high enantiomer-discrimination ability of the catalyst achieves an excellent stereoselectivity factor (s = k(fast)/k(slow)) of 261 in the best case. A catalytic cycle for this reaction is proposed.

  DOI：

  10.1021/jo201940w

文献信息

• Kinetic Resolution of Racemic α-tert-Alkyl-α-hydroxy Esters by Enantiomer-Selective Carbamoylation
  作者：Nobuhito Kurono、Kentaro Ohtsuga、Masanori Wakabayashi、Tadahiro Kondo、Hirohito Ooka、Takeshi Ohkuma

  DOI：10.1021/jo201940w

  日期：2011.12.16

  Kinetic resolution of sterically hindered racemic alpha-tert-alkyl-alpha-hydroxy esters is performed by enantiomer-selective carbamoylation with the t-Bu-Box-Cu(II) catalyst (Box = bis(oxazoline)). The reaction with 0.5 equiv of n-C3H7NCO is carried out with a substrate-to-catalyst molar ratio of 500-5000 at -20 to 25 degrees C. The high enantiomer-discrimination ability of the catalyst achieves an excellent stereoselectivity factor (s = k(fast)/k(slow)) of 261 in the best case. A catalytic cycle for this reaction is proposed.