2-(2-methoxyphenyl)-4-(trifluoromethyl)-N-[1-[3-(dimethylamino)phenyl]ethyl]-5-thiazolecarboxamide | 725247-80-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(2-methoxyphenyl)-4-(trifluoromethyl)-N-[1-[3-(dimethylamino)phenyl]ethyl]-5-thiazolecarboxamide
• 英文别名: N-[1-[3-(dimethylamino)phenyl]ethyl]-2-(2-methoxyphenyl)-4-(trifluoromethyl)-5-thiazolecarboxamide；N-[1-[3-(dimethylamino)phenyl]ethyl]-2-(2-methoxyphenyl)-4-(trifluoromethyl)-1,3-thiazole-5-carboxamide
• CAS: 725247-80-3
• 化学式: C₂₂H₂₂F₃N₃O₂S
• 分子量: 449.497
• InChiKey: INGPBWSVMDCISP-UHFFFAOYSA-N

物化性质

• 密度：
  1.279±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  82.7
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• 2-aryl thiazole derivatives as KCNQ modulators
  申请人：——

  公开号：US20040147401A1

  公开（公告）日：2004-07-29

  Novel 2-arylthiazole derivatives of Formula I are described which are openers of KCNQ potassium channels and are useful in the treatment of disorders that are responsive to the opening of the KCNQ potassium channels, including pain and migraine. 1

  公式I的新型2-芳基噻唑衍生物被描述为KC NQ钾通道的开启剂，并且在治疗对KC NQ钾通道的开启有响应的疾病，包括疼痛和偏头痛方面具有用处。
• US7273866B2
  申请人：——

  公开号：US7273866B2

  公开（公告）日：2007-09-25
• [EN] 2-ARYL THIAZOLE DERIVATIVES AS KCNQ MODULATORS<br/>[FR] DÉRIVÉS DE 2-ARYLTHIAZOLE UTILISÉS COMME MODULATEURS DE KCNQ
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2004060281A2

  公开（公告）日：2004-07-22

  Novel 2-arylthiazole derivatives of Formula (I) are described which are openersof KCNQ potassium channels and are useful in the treatment of disorders thatare responsive to the opening of the KCNQ potassium channels, including pain andmigraine.