(S)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol | 1221183-88-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol
• CAS: 1221183-88-5
• 化学式: C₁₂H₁₅NO₅
• 分子量: 253.255
• InChiKey: DPTTWIJAEHFMBP-SNVBAGLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.75
• 重原子数：
  18.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  81.83
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  3,4-二甲氧基苯丙酮 在 葡萄糖 作用下， 以 二甲基亚砜 为溶剂， 反应 24.0h， 以51.5%的产率得到(S)-1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanol
  参考文献：
  名称：

  Wickerhamomyces subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of ketones

  摘要：

  Newly isolated strains of Wickerhamomyces subpelliculosus were recognized as excellent whole cell biocatalyst for bioreduction of various ketones. The biocatalytic properties of the new strains were demonstrated in this study by stereoselective bioreduction of acetophenone la, 2-heptanone lb, phenylacetone 1c, 3,4-dimethoxyphenylacetone id and 1-cyclopropy1-2-(2-methoxy4-nitrophenoxy)ethanone le. Our study is the first report on application of W. subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of prochiral ketones. In these processes, both the freshly harvested cell paste and the lyophilized cell powder were tested as biocatalyst using glucose or 2-propanol at various concentrations as cosubstrates for cofactor regeneration. The newly isolated strains of W. subpelliculosus showed diverse characteristics, including optimal pH, temperature and organic solvent tolerance. Bioreductions of phenylacetone 1c applying glucose as cosubstrate under various mild conditions resulted (S)-1-phenylpropanol [(S)-2c] in good to excellent conversion (c = 63.4%-99.9%) with excellent enantiomeric excess [ee((s)-2c) = 98.7%-99.8%]. (C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcatb.2016.11.003

文献信息

• [EN] PYRROLONE MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS<br/>[FR] ANTAGONISTES DE RÉCEPTEUR D'HORMONE CONCENTRANT LA MÉLANINE 1 DE TYPE PYRROLONE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2010042674A1

  公开（公告）日：2010-04-15

  The present application provides compounds, including all stereoisomers, solvates, prodrugs and pharmaceutically acceptable forms thereof according to Formula I wherein R1, Formula Ia, R4, R5, Formula Ib, R3, R3a, W, D, R2a, R2b and R2c are defined herein. Additionally, the present application provides pharmaceutical compositions containing at least one compound according to Formula I and optionally at least one additional therapeutic agent. Finally, the present application provides methods for treating a patient suffering from an MCHR-1 modulated disease or disorder such as, for example, obesity, diabetes, depression, anxiety or intestinal inflammation, by administration of a therapeutically effective dose of a compound according to Formula I.

  本申请提供了根据公式I提供的化合物，包括所有立体异构体、溶剂合物、前药和药用可接受形式，其中R1、公式Ia、R4、R5、公式Ib、R3、R3a、W、D、R2a、R2b和R2c在此处定义。此外，本申请提供了含有至少一种根据公式I的化合物和可选至少一种额外治疗剂的药物组合物。最后，本申请提供了治疗患有MCHR-1调节性疾病或紊乱的患者的方法，例如肥胖、糖尿病、抑郁症、焦虑或肠道炎症，通过给予根据公式I的化合物的治疗有效剂量。
• HYDROXY SUBSTITUTED THIENO PYRIMIDINONES AS MELANIN CONCENTRATING HORMONE RECEPTOR-1 ANTAGONISTS
  申请人：Washburn William N.

  公开号：US20090298794A1

  公开（公告）日：2009-12-03

  The present invention provides compounds having the following Formula IA and IB, which are useful as MCHR1 antagonists, and includes prodrugs and pharmaceutically acceptable salts thereof:

  本发明提供了具有以下化学式IA和IB的化合物，这些化合物可作为MCHR1拮抗剂使用，并包括其前药和药用盐：