| 1257860-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• CAS: 1257860-93-7
• 化学式: C₁₈H₁₉F₂N₅O₂
• 分子量: 375.378
• InChiKey: JKFOVDDJWNMBHB-OKILXGFUSA-N

反应信息

• 作为产物：
  描述：

  在 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases

  摘要：

  Inhibition of histone deacetylase activity represents a promising new modality in the treatment of a number of cancers. A novel HDAC series demonstrating inhibitory activity in cell proliferation assays is described. Optimisation based on the introduction of basic amine linkers to effect good drug distribution to tumour led to the identification of a compound with oral activity in a human colon cancer xenograft study associated with increased histone H3 acetylation in tumour tissue. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.09.016