4-[4-(甲基氨基)苯基]苯胺 | 2655-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[4-(甲基氨基)苯基]苯胺
• 英文名称: N-methyl-benzidine
• 英文别名: N-Methyl-benzidin；4-amino-4'-methylaminobiphenyl；4-Amino-4'-methylaminbiphenyl；N-Methylbenzidin；(1,1'-Biphenyl)-4,4'-diamine, N-methyl-；4-[4-(methylamino)phenyl]aniline
• CAS: 2655-67-6
• 化学式: C₁₃H₁₄N₂
• 分子量: 198.268
• InChiKey: RGAHQZJIKHEKOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  38
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-[4-(甲基氨基)苯基]苯胺 在 盐酸 、 sodium nitrite 作用下， 生成 [4'-(4-dimethylamino-phenylazo)-biphenyl-4-yl]-methyl-nitroso-amine
  参考文献：
  名称：

  Rassow; Berger, Journal fur praktische Chemie (Leipzig 1954), 1911, vol. <2>84, p. 274

  摘要：

  DOI：
• 作为产物：
  描述：

  N,N'-[3,3']bicyclohexa-1,4-dienylidene-6,6'-diylidene-bis-benzenesulfonamide 在 sodium hydroxide 、 硫酸 作用下， 生成 4-[4-(甲基氨基)苯基]苯胺
  参考文献：
  名称：

  有机磷化合物—X ：亚磷酸三烷基酯与扩展的对醌的反应

  摘要：

  亚磷酸三甲酯和亚乙基三乙酯与联苯醌3反应，生成4,4'-二羟基联苯10；4'-烷氧基-4-联苯基二烷基磷酸盐5，4,4'-亚联苯基四烷基双（磷酸酯），6，和4'-羟基-4-联苯基二烷基磷酸盐9在次要的产率也分离。研究了温度对反应的影响。提出了反应的机理，其解释了实验结果。亚磷酸三甲酯和亚磷酸三乙酯与醌亚胺12的反应以定量收率得到了相应的氨基磷酸酯13。

  DOI：

  10.1016/s0040-4020(01)97215-1

文献信息

• [EN] COMPOUNDS FOR INHIBITING DRUG-RESISTANT STRAINS OF HIV-1 INTEGRASE<br/>[FR] COMPOSÉS POUR INHIBER DES SOUCHES RÉSISTANTES AUX MÉDICAMENTS D'INTÉGRASE DE VIH-1
  申请人：US HEALTH

  公开号：WO2014186398A1

  公开（公告）日：2014-11-20

  A method of inhibiting drug -resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z1-Z5 is independently H or halogen; R4 is H, OH, NH2, NHR8, NR8R9 or R8; R5, R6, and R7 is each independently H, halogen, OR8, R8, NHR8, NR8R9, CO2R8, CONR8R9, SO2NR8R9, or R5 and R6 together with the carbon atoms to which R5 and R6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R8 and R9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally- substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R8 and R9 together with the nitrogen to which R8 and R9 are attached form an optionally-substituted heterocycle.

  在需要的患者中给予一种化合物（公式I）的治疗有效量，或其药用盐或酯，以抑制患者体内的耐药HIV-1整合酶。该化合物的结构为：其中X为N、C（OH）或CH；Y为H或OH；Z1-Z5中的每一个独立地为H或卤素；R4为H、OH、NH2、NHR8、NR8R9或R8；R5、R6和R7每一个独立地为H、卤素、OR8、R8、NHR8、NR8R9、CO2R8、CONR8R9、SO2NR8R9，或者R5和R6与其连接的碳原子形成一个可选择取代的碳环或可选择取代的杂环；R8和R9每一个独立地为H、可选择取代的烷基、可选择取代的烯基、可选择取代的炔基、可选择取代的芳基、可选择取代的环烷基、可选择取代的环烷基烯、可选择取代的杂环、可选择取代的酰胺、可选择取代的酯，或者R8和R9与其连接的氮原子形成一个可选择取代的杂环。
• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• COMPOUNDS FOR INHIBITING DRUG-RESISTANT STRAINS OF HIV-1 INTEGRASE
  申请人：THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SEC., DEPT. OF HEALTH AND HUMAN SERVICES

  公开号：US20160083382A1

  公开（公告）日：2016-03-24

  A method of inhibiting drug-resistant HIV-1 integrase in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula I, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is N, C(OH), or CH; Y is H or OH; each of Z 1 -Z 5 is independently H or halogen; R 4 is H, OH, NH 2 , NHR 8 , NR 8 R 9 or R 8 ; R 5 , R 6 , and R 7 is each independently H, halogen, OR 8 , R 8 , NHR 8 , NR 8 R 9 , CO 2 R 8 , CONR 8 R 9 , SO 2 NR 8 R 9 , or R 5 and R 6 together with the carbon atoms to which R 5 and R 6 are attached form an optionally-substituted carbocycle or optionally-substituted heterocycle; and R 8 and R 9 is each independently H, optionally-substituted alkyl, optionally-substituted alkenyl, optionally-substituted alkynyl, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted cycloalkylene, optionally-substituted heterocycle, optionally-substituted amide, optionally-substituted ester, or R 8 and R 9 together with the nitrogen to which R 8 and R 9 are attached form an optionally-substituted heterocycle.

  本方法涉及在需要抑制药物耐药性HIV-1整合酶的主体中向其施用公式I的化合物的治疗有效量，或其药学上可接受的盐或酯，其结构为：其中X为N，C（OH）或CH；Y为H或OH；Z1-Z5中的每一个独立为H或卤素；R4为H，OH，NH2，NHR8，NR8R9或R8；R5、R6和R7各自独立为H，卤素，OR8，R8，NHR8，NR8R9，CO2R8，CONR8R9，SO2NR8R9或R5和R6与R5和R6附着的碳原子一起形成可选地取代的碳环或可选地取代的杂环；R8和R9各自独立为H，可选地取代的烷基，可选地取代的烯基，可选地取代的炔基，可选地取代的芳基，可选地取代的环烷基，可选地取代的环烷基，可选地取代的杂环，可选地取代的酰胺，可选地取代的酯，或R8和R9与R8和R9附着的氮一起形成可选地取代的杂环。
• Beta-diketo-compound-polymer reaction product and use thereof
  申请人：International Business Machines Corporation

  公开号：EP0340392A2

  公开（公告）日：1989-11-08

  A reaction product of a β-diketone and a polymer having groups that are reactive with the β-diketone can be complexed with a metal. The reaction product having the complex metal can be activated to provide a substrate suitable for plating from an electroless metal plating bath.

  β-二酮和具有与β-二酮反应基团的聚合物的反应产物可与金属络合。具有络合金属的反应产物可被活化，以提供适合从无电解金属电镀液中电镀的基底。
• Electrochromic device
  申请人：Nippon Mitsubishi Oil Corporation

  公开号：EP0995786A1

  公开（公告）日：2000-04-26

  The electrochromic device which has an ion conductive layer obtained by curing a composition comprising (a) a bipyridinium compound represented by formula (1), (b) a specific amine compound and (c) a precursor component of a polymeric solid electrolyte, disposed between two electrically conductive substrates at least one of which is transparent, said formula (1) being wherein X- and Y- are the same or different and are each independently a counter anion selected from the group consisting of an halogen anion, ClO4-, BF4-, PF6-, CH3COO- and CH3(C6H4)SO3-, R1 is hydrogen or a C1 - C5 alkyl group, R2 is a C1 - C30 divalent hydrocarbon or oxygen-containing hydrocarbon group, R3 is a C1 - C20 hydrocarbon or oxygen-containing hydrocarbon group and a is an integer of 0 or 1.

  电致变色装置，其离子导电层是通过固化一种组合物而获得的，该组合物包括(a) 由式(1)表示的联吡啶鎓化合物，(b) 特定胺化合物和(c) 聚合物固体电解质的前体组分，置于两个导电基底之间，其中至少有一个基底是透明的、 所述式（1）为 其中 X- 和 Y- 相同或不同，且各自独立地为选自卤素阴离子、ClO4-、BF4-、PF6-、CH3COO- 和 CH3(C6H4)SO3- 的反阴离子，R1 为氢或 C1 - C5 烷基，R2 为 C1 - C30 二价烃或含氧烃基，R3 为 C1 - C20 烃或含氧烃基，a 为 0 或 1 的整数。