1-isonicotinoyl-2-formylhydrazine | 89792-19-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-isonicotinoyl-2-formylhydrazine
• 英文别名: N-formyl-N'-isonicotinoyl-hydrazine；N-Formyl-N'-isonicotinoyl-hydrazin；N-(pyridine-4-carbonylamino)formamide
• CAS: 89792-19-8
• 化学式: C₇H₇N₃O₂
• 分子量: 165.151
• InChiKey: HGQYWVZOJDHKSM-UHFFFAOYSA-N

物化性质

• 密度：
  1.278±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-isonicotinoyl-2-formylhydrazine 、 2-萘胺 以 甲醇 为溶剂， 以63%的产率得到4-(4-(naphthalen-2-yl)-4H-1,2,4-triazol-3-yl)pyridine
  参考文献：
  名称：

  Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

  摘要：

  In this Letter, we describe the evolution of selective JNK3 inhibitors from 1, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs. Strong SAR was found for substitution of the naphthalene ring, as well as for inhibitors adopting different central scaffolds. Significant potency gains were appreciated by inverting the polarity of the thione of the parent triazolothione 1, resulting in potent compounds with attractive pharmacokinetic profiles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.074
• 作为产物：
  描述：

  异烟肼 、 甲酸乙酯 以45%的产率得到1-isonicotinoyl-2-formylhydrazine
  参考文献：
  名称：

  Highly selective c-Jun N-terminal kinase (JNK) 3 inhibitors with in vitro CNS-like pharmacokinetic properties II. Central core replacement

  摘要：

  In this Letter, we describe the evolution of selective JNK3 inhibitors from 1, that routinely exhibit >10-fold selectivity over JNK1 and >1000-fold selectivity over related MAPKs. Strong SAR was found for substitution of the naphthalene ring, as well as for inhibitors adopting different central scaffolds. Significant potency gains were appreciated by inverting the polarity of the thione of the parent triazolothione 1, resulting in potent compounds with attractive pharmacokinetic profiles. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.04.074

文献信息

• Heterocyclic Compounds as Pesticides
  申请人：Bretschneider Thomas

  公开号：US20110212949A1

  公开（公告）日：2011-09-01

  The present application relates to the use of heterocyclic compounds, some of which are known, for controlling animal pests, including arthropods and in particular insects, furthermore to novel heterocyclic compounds and to processes for their preparation.

  本申请涉及使用杂环化合物来控制动物害虫，包括节肢动物，特别是昆虫，此外还涉及新型杂环化合物及其制备方法。
• Chemotherapy of Experimental Tuberculosis. VIII. The Synthesis of Acid Hydrazides, their Derivatives and Related Compounds^1,2
  作者：Harry L. Yale、Kathryn Losee、Joseph Martins、Mary Holsing、Frances M. Perry、Jack Bernstein

  DOI：10.1021/ja01104a046

  日期：1953.4
• Hearn, Michael J.; Kang, Helen Joo On; Thai, Minh, Bulletin des Societes Chimiques Belges, 1997, vol. 106, # 2, p. 109 - 114
  作者：Hearn, Michael J.、Kang, Helen Joo On、Thai, Minh

  DOI：——

  日期：——
• Novotny et al., Cesko-Slovenska Farmacie, 1958, vol. 7, p. 517
  作者：Novotny et al.

  DOI：——

  日期：——
• ISONIAZID MEDIATED HEALING OF WOUNDS AND ULCERS
  申请人：Pharma 2100

  公开号：EP2068873A2

  公开（公告）日：2009-06-17