| 1428675-24-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• CAS: 1428675-24-4
• 化学式: C₁₄H₁₁BrN₄O₄
• 分子量: 379.17
• InChiKey: JUIONWVULPGGLH-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  C₅H₄BrNO₂ 、 3-叠氮基-7-羟基氧杂萘邻酮 在 sodium ascorbate 作用下， 以 aq. buffer 为溶剂， 生成
  参考文献：
  名称：

  Relative Performance of Alkynes in Copper-Catalyzed Azide–Alkyne Cycloaddition

  摘要：

  Copper-catalyzed azide-alkyne cycloaddition (CuAAC) has found numerous applications in a variety of fields. We report here only modest differences in the reactivity of various classes of terminal alkynes under typical bioconjugative and preparative organic conditions. Propargyl compounds represent an excellent combination of azide reactivity, ease of installation, and cost. Electronically activated propiolamides are slightly more reactive, at the expense of increased propensity for Michael addition. Certain alkynes, including tertiary propargyl carbamates, are not suitable for bioconjugation due to copper-induced fragmentation. A fluorogenic probe based on such reactivity is available in one step from rhodamine 110 and can be useful for optimization of CuAAC conditions.

  DOI：

  10.1021/bc300672b