[Pd(3,4-dichloroacetophenone thiosemicarbazone)(PPh3)] | 1248782-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [Pd(3,4-dichloroacetophenone thiosemicarbazone)(PPh3)]
• CAS: 1248782-22-0
• 化学式: C₂₇H₂₂Cl₂N₃PPdS
• 分子量: 628.858
• InChiKey: DBGXOOFGEYQWAA-XNYNPNPSSA-M

反应信息

• 作为产物：
  描述：

  3,4-dichloroacetophenone thiosemicarbazone 以 乙醇 、 水 、 丙酮 为溶剂， 生成 [Pd(3,4-dichloroacetophenone thiosemicarbazone)(PPh3)]
  参考文献：
  名称：

  Cyclopalladated complexes containing tridentate thiosemicarbazone ligands of biological significance: Synthesis, structure and antimalarial activity

  摘要：

  The C-H activation reaction of two aryl-derived thiosemicarbazones with K-2[PdCl4] affords tetranuclear cyclopalladated complexes (3 and 4) where the thiosemicarbazone ligand acts as a tridentate donor [C,N,S] coordinated to palladium via the ortho-carbon of the aryl ring, imine nitrogen and thiolato sulfur. The palladiumesulfur bridging coordination bonds give rise to a Pd4S4 core. These Pd-S-bridging bonds were cleaved with a variety of mono-and bis-phosphines to give a series of mono, di and tetranuclear organopalladium complexes (5-12) where the phosphorus atom coordinates to palladium trans to the imine nitrogen. All of the complexes were fully characterized using various analytical and spectroscopic techniques. These palladium complexes along with their free ligands were evaluated as bioorganometallic antimalarial agents against two Plasmodium falciparum strains, 3D7 (chloroquine sensitive) and K1 (chloroquine and pyrimethamine resistant). Some of the complexes were found to be moderate inhibitors of parasite growth and were more active than the corresponding free ligand. (C) 2010 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.06.010
• 作为试剂：
  描述：

  4-碘苯甲醚 、 苯硼酸 在 potassium phosphate 、 [Pd(3,4-dichloroacetophenone thiosemicarbazone)(PPh3)] 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以95%的产率得到4-甲氧基联苯
  参考文献：
  名称：

  Cyclometallated Pd(II) thiosemicarbazone complexes: new catalyst precursors for Suzuki-coupling reactions

  摘要：

  Four tridentate [C,N,S] thiosemicarbazone Pd(II) complexes were applied as catalyst precursors for the Suzuki-Miyaura coupling of a variety of aryl halides and aryl boronic acids. After screening various catalytic conditions, it was found that one dinuclear complex IV containing the bis(diphenylphosphino) ferrocene spacer was able to efficiently catalyze these reactions with yields up to 99% irrespective of the type of aryl substituent on the substrate. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.10.115