4-[4-（1-吡咯烷基）苯基]-1,3-噻唑-2-基胺 | 784136-89-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 中文名称: 4-[4-（1-吡咯烷基）苯基]-1,3-噻唑-2-基胺
• 英文名称: 4-(4-pyrrolidin-1-yl-phenyl)-thiazol-2-yl-amine
• 英文别名: 4-[4-(1-Pyrrolidinyl)phenyl]-1,3-thiazol-2-ylamine；4-(4-pyrrolidin-1-ylphenyl)-1,3-thiazol-2-amine
• CAS: 784136-89-6
• 化学式: C₁₃H₁₅N₃S
• 分子量: 245.348
• InChiKey: LAAAYLCXBDADNM-UHFFFAOYSA-N

物化性质

• 熔点：
  228-230°C

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  70.4
• 氢给体数：
  1
• 氢受体数：
  4

安全信息

• 危险等级：
  IRRITANT

反应信息

• 作为产物：
  描述：

  硫脲 、 2-溴-4’-(1-吡咯烷基)苯乙酮 以 乙醇 为溶剂， 反应 0.5h， 以95%的产率得到4-[4-（1-吡咯烷基）苯基]-1,3-噻唑-2-基胺
  参考文献：
  名称：

  Design and synthesis of 2-aminothiazole based antimicrobials targeting MRSA

  摘要：

  Privileged structure-based libraries have been shown to provide high affinity lead compounds for a variety of important biological targets. The present study describes the synthesis and screening of a 2-aminothiazole based compound library to determine their utility as antimicrobials, focusing on MRSA. Several of the compounds in this series demonstrated improved antimicrobial activity as compared to ceftriaxone (CTX), a beta-lactam antibiotic. The most potent compound (21) had MICs in the range of 24 mu g/ml across a panel of Staphylococcus aureus strains. In addition, trifluoromethoxy substituted aminothiazoles and aminobenzothiazoles were found to be potent antimicrobials with MICs of 2-16 mu g/ml. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.09.095

文献信息

• Urea Derivatives Methods For Their Manufacture And Uses Thereof
  申请人：DePrez Pierre

  公开号：US20100240889A1

  公开（公告）日：2010-09-23

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式（I）的化合物：其中R1，R′1，R2，R′2，R3，Y和G具有描述中给出的含义，以及它们的制备过程，它们通过药物的方式应用，以及含有它们的制药组合物。
• UREA DERIVATIVES, METHODS FOR THEIR MANUFACTURE, AND USES THEREFOR
  申请人：DEPREZ Pierre

  公开号：US20120283255A1

  公开（公告）日：2012-11-08

  The present invention provides compounds of formula (I): in which R 1 , R′ 1 , R 2 , R′ 2 , R 3 , and Y have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了公式（I）的化合物：其中R1，R′1，R2，R′2，R3和Y具有描述中给出的含义，以及它们的制备方法，通过药物的方式应用它们，以及包含它们的制药组合物。
• Urea derivatives, methods for their manufacture, and uses thereof
  申请人：Galapagos SAS

  公开号：EP2354137A1

  公开（公告）日：2011-08-10

  The present invention provides compounds of formula (I): in which R1, R'1, R2, R'2, R3, Y and G have the meanings given in the description, to a process for their preparation, their application by way of medicaments, and to pharmaceutical compositions containing them.

  本发明提供了式 (I) 的化合物： 中 R1、R'1、R2、R'2、R3、Y 和 G 的含义，以及它们的制备工艺、它们在药物中的应用和含有它们的药物组合物。
• Novel compounds for inhibition of Tie-2
  申请人：KYLIX, B.V.

  公开号：US20030158199A1

  公开（公告）日：2003-08-21

  The present invention provides a method of inhibiting or moderating the kinase activity of tyrosine kinases comprising the administration of a compound represented by formula (1) said kinase in sufficient concentration to inhibit or moderate the enzyme activity of said kinase.

  本发明提供了一种抑制或缓和酪氨酸激酶活性的方法，包括施用足够浓度的式 (1) 所代表的化合物来抑制或缓和所述激酶的酶活性。
• UREA DERIVATIVES METHODS FOR THEIR MANUFACTURE AND USES THEREOF
  申请人：Proskelia SAS

  公开号：EP1874765A2

  公开（公告）日：2008-01-09