({3-[4-(Benzofuran-2-carbonyl)-phenoxy]-3-phenyl-propyl}-methyl-amino)-acetic Acid | 772331-33-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: ({3-[4-(Benzofuran-2-carbonyl)-phenoxy]-3-phenyl-propyl}-methyl-amino)-acetic Acid
• 英文别名: 2-[[3-[4-(1-Benzofuran-2-carbonyl)phenoxy]-3-phenylpropyl]-methylamino]acetic acid
• CAS: 772331-33-6
• 化学式: C₂₇H₂₅NO₅
• 分子量: 443.499
• InChiKey: YMTAMCJVUDYRCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  80
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Benzophenones and sulfones as inhibitors of glycine uptake
  申请人：Pfizer Inc.

  公开号：US20020052401A1

  公开（公告）日：2002-05-02

  This invention relates to a series of substituted benzophenone and sulfone compounds of the formula I 1 wherein ring A, Z, Y, R and X are defined as in the specification, that exhibit activity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.

  这项发明涉及一系列符合以下式I的取代苯并酮和砜化合物： 其中环A、Z、Y、R和X的定义如规范中所述，这些化合物表现出作为甘氨酸转运抑制剂的活性，它们的药学上可接受的盐，含有它们的药物组合物，以及它们用于增强认知和治疗哺乳动物，包括人类，的精神分裂症和其他精神病阳性和阴性症状的用途。
• BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE
  申请人：Pfizer Products Inc.

  公开号：EP1294677A1

  公开（公告）日：2003-03-26
• US6506780B2
  申请人：——

  公开号：US6506780B2

  公开（公告）日：2003-01-14
• [EN] BENZOPHENONES AND SULFONES AS INHIBITORS OF GLYCINE UPTAKE<br/>[FR] BENZOPHENONES ET SULFONES COMME INHIBITEURS DE LA CAPTURE DU GLYCOCOLLE
  申请人：PFIZER PROD INC

  公开号：WO2002000602A1

  公开（公告）日：2002-01-03

  This invention relates to a series of substituted benzophenone and sulfone compounds of the formula (I) that exhibit acitivity as glycine transport inhibitors, their pharmaceutically acceptable salts, pharmaceutical compositions containing them, and their use for the enhancement of cognition and the treatment of the positive and negative symptoms of schizophrenia and other psychoses in mammals, including humans.