| 1351391-14-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• CAS: 1351391-14-4
• 化学式: C₄₂H₄₉N₇O₉S₂
• 分子量: 860.025
• InChiKey: PLCLUJHFSXHMPZ-DHAVCDPWSA-N

反应信息

• 作为产物：
  描述：

  [(1S,4R,6S,18R)-4-(cyclopropylsulfonylcarbamoyl)-18-[7-methoxy-8-methyl-2-(4-propan-2-yl-1,3-thiazol-2-yl)quinolin-4-yl]oxy-2,15-dioxo-3,16-diazatricyclo[14.3.0.04,6]nonadec-7-en-14-yl] 2,2-dimethylpropanoate 在 sodium methylate 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 3.5h， 生成
  参考文献：
  名称：

  Discovery of novel P3-oxo inhibitor of hepatitis C virus NS3/4A serine protease

  摘要：

  A novel series of P3 oxo-modified macrocyclic hepatitis C virus NS3/4A serine protease inhibitor was designed, synthesized and biologically evaluated. The hydroxy-substituted inhibitor 10 demonstrated high potency in genotype 1a and 1b replicon and in the panel of HCV protease mutants. Interestingly, the t-butyl carbonate analog 9c, while not the most potent one in this series, exhibited a virtually flat potency profile in the panel of HCV protease mutants, thus providing opportunity for further optimization. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2012.02.039