4-thiothymidine-5'-triphosphate | 20456-29-5

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: 4-thiothymidine-5'-triphosphate
• 英文别名: 4-Thiothymidine 5'-(tetrahydrogen triphosphate)；[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2-oxo-4-sulfanylidenepyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl] phosphono hydrogen phosphate
• CAS: 20456-29-5
• 化学式: C₁₀H₁₇N₂O₁₃P₃S
• 分子量: 498.238
• InChiKey: LZAPTRCZOHFNTH-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.4
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  254
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• METHOD TO DETECT ACTIVITY OF A POLYMERASE
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：EP3098322A1

  公开（公告）日：2016-11-30

  The present invention relates to methods for detection of nucleotide polymerase activity and methods of detecting compounds that modulate nucleotide polymerase activity, by detecting product formation of the nucleotide polymerase to be tested based on determination of close proximity of two labeled nucleotide probes able to bind the product of the nucleotide polymerase. It is preferred that proximity dependent energy transfer, such as förster resonance energy transfer, between said labeled nucleotide probes is determined. The invention further provides kits comprising components for carrying out the inventive methods for detection of nucleotide polymerase activity.

  本发明涉及核苷酸聚合酶活性的检测方法和调节核苷酸聚合酶活性的化合物的检测方法，其方法是根据能够结合核苷酸聚合酶产物的两个标记核苷酸探针的近距离测定来检测待测核苷酸聚合酶的产物形成。最好是确定所述标记的核苷酸探针之间的能量转移（如佛斯特共振能量转移）与距离有关。本发明进一步提供了试剂盒，试剂盒中包含用于实施本发明核苷酸聚合酶活性检测方法的组件。
• Functional ligands to nerve agent metabolites
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US10059951B2

  公开（公告）日：2018-08-28

  This invention relates to functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, more particularly to functional ligands with binding affinity to metabolites of nerve agents, and further particularly to functional ligands with binding affinity to metabolites of VX-acid (metabolite of VX nerve agent) and GB-acid (metabolite of sarin nerve agent).

  本发明涉及目标分子的功能配体，特别是功能核酸及其修饰，更特别的是与神经毒剂代谢物具有结合亲和力的功能配体，进一步特别是与 VX 酸（VX 神经毒剂的代谢物）和 GB 酸（沙林神经毒剂的代谢物）的代谢物具有结合亲和力的功能配体。
• Functional ligands to target molecules
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US10415041B2

  公开（公告）日：2019-09-17

  The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as amino acids, such as citrulline, and to target molecules such as crystallin or its subunits, such as alpha crystallin B-chain (CRYAB).

  本发明涉及与靶分子有关的功能配体，特别是与功能核酸及其修饰有关的功能配体，以及同时产生例如多种不同功能生物分子的方法，特别是同时针对多个靶分子产生多种不同功能核酸的方法。本发明进一步涉及与目标分子（如氨基酸，如瓜氨酸）和目标分子（如结晶素或其亚基，如α结晶素B链（CRYAB））亲和结合的功能配体。
• Bioagent detection oligonucleotides
  申请人：IBIS BIOSCIENCES, INC.

  公开号：US10662485B2

  公开（公告）日：2020-05-26

  The present invention compositions, methods and systems to identify, detect, and/or quantify bacterial DNA in the presence of contaminating non-bacterial DNA. In particular, the present invention provides oligonucleotides configured to detect a relatively small amount of bacterial DNA in the presence of an overwhelmingly large amount of contaminating human DNA.

  本发明的组合物、方法和系统可在有非细菌 DNA 污染的情况下识别、检测和/或量化细菌 DNA。特别是，本发明提供的寡核苷酸可在大量人类 DNA 污染的情况下检测相对少量的细菌 DNA。
• Functional ligands to THC
  申请人：Base Pair Biotechnologies, Inc.

  公开号：US10676781B2

  公开（公告）日：2020-06-09

  The present invention relates functional ligands to target molecules, particularly to functional nucleic acids and modifications thereof, and to methods for simultaneously generating, for example, numerous different functional biomolecules, particularly to methods for generating numerous different functional nucleic acids against multiple target molecules simultaneously. The present invention further relates to functional ligands which bind with affinity to target molecules, such as tetrahydrocannabinol (THC).

  本发明涉及与靶分子相关的功能配体，特别是功能核酸及其修饰，以及同时产生例如多种不同功能生物分子的方法，特别是同时针对多个靶分子产生多种不同功能核酸的方法。本发明进一步涉及与四氢大麻酚（THC）等靶分子亲和结合的功能配体。