4-(dimethoxymethyl)-3-fluorobenzaldehyde | 439814-88-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(dimethoxymethyl)-3-fluorobenzaldehyde
• CAS: 439814-88-7
• 化学式: C₁₀H₁₁FO₃
• 分子量: 198.194
• InChiKey: YIOQIBDBHZBZSM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(dimethoxymethyl)-3-fluorobenzaldehyde 、 乙基溴化镁 以 乙醚 为溶剂， 反应 16.0h， 生成 1-[4-(dimethoxymethyl)-3-fluorophenyl]propan-1-ol
  参考文献：
  名称：

  Therapeutic diphenyl ether ligands

  摘要：

  该发明涉及式Ia、Ib或Ic的化合物，以及其药物组成物：或其前药和药用可接受载体，其中R基在规范中定义；以及虚线代表可选的双键。该发明还涉及治疗、诊断和预防与5HT受体相关的中枢神经系统疾病的方法，包括肥胖、注意缺陷障碍、偏头痛、抑郁症、癫痫、焦虑、阿尔茨海默病、戒毒、疼痛、精神分裂症、应激相关疾病、恐慌症、睡眠障碍、恐惧症、强迫症、创伤后应激综合征、免疫系统抑郁、应激引起的胃肠功能障碍、应激引起的心血管功能障碍和性功能障碍。

  公开号：

  US20060058361A1
• 作为产物：
  描述：

  4-溴-1-(二甲氧基甲基)-2-氟苯 在 正丁基锂 作用下， 以 四氢呋喃 、 N-甲基乙酰胺 、 水 为溶剂， 以63%的产率得到4-(dimethoxymethyl)-3-fluorobenzaldehyde
  参考文献：
  名称：

  Telomerase inhibitors and methods of their use

  摘要：

  本文提供了噻唑烷二酮化合物、组合物和方法，用于体外抑制端粒酶活性以及体内和体外治疗由端粒酶介导的疾病或病症。本发明的方法、化合物和组合物可以单独使用，也可以与其他药理活性剂结合在一起，用于治疗由端粒酶活性介导的疾病或病症，例如癌症的治疗。还公开了用于检测或筛选端粒酶活性抑制剂的方法。

  公开号：

  US20020120144A1

文献信息

• THERAPEUTIC DIPHENYL ETHER LIGANDS
  申请人：Pfizer Products Incorporated

  公开号：EP1791807A1

  公开（公告）日：2007-06-06
• US6452014B1
  申请人：——

  公开号：US6452014B1

  公开（公告）日：2002-09-17
• [EN] TELOMERASE INHIBITORS AND METHODS OF THEIR USE<br/>[FR] INHIBITEURS DE LA TELOMERASE ET LEURS PROCEDES D'UTILISATION
  申请人：GERON CORP

  公开号：WO2002051409A1

  公开（公告）日：2002-07-04

  Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.
• [EN] THERAPEUTIC DIPHENYL ETHER LIGANDS<br/>[FR] LIGANDS DE DIPHENYL ETHER THERAPEUTIQUES
  申请人：PFIZER PROD INC

  公开号：WO2006027684A1

  公开（公告）日：2006-03-16

  This invention is directed to compounds of formula la, lb or Ic and to pharmaceutical compositions thereof: formula (Ia), formula (Ib), formula (Ic) or a prodrug thereof and a pharmaceutically acceptable carrier, wherein the R groups are defined in the specification; and, in which the dashed line represents an optional double bond. The invention is also directed to methods of treating, diagnosing, and preventing disorders of the central nervous system that are associated with 5HT receptors, including obesity, attention deficit disorder, migraine, depression, epilepsy, anxiety, Alzheimer's disease, withdrawal from drug abuse, pain, schizophrenia, stress-related disorders, panic disorder, sleep disorders, phobias, obsessive compulsive disorder, post-traumatic-stress syndrome, immune system depression, stress-induced gastrointestinal dysfunction, stress-induced cardiovascular dysfunction, and sexual dysfunction.
• Telomerase inhibitors and methods of their use
  申请人：——

  公开号：US20020120144A1

  公开（公告）日：2002-08-29

  Thiazolidinedione compounds, compositions, and methods of inhibiting telomerase activity in vitro and treatment of telomerase mediated conditions or diseases ex vivo and in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of conditions or diseases mediated by telomerase activity, such as in the treatment of cancer. Also disclosed are methods for assaying or screening for inhibitors of telomerase activity.

  本文提供了噻唑烷二酮化合物、组合物和方法，用于体外抑制端粒酶活性以及体内和体外治疗由端粒酶介导的疾病或病症。本发明的方法、化合物和组合物可以单独使用，也可以与其他药理活性剂结合在一起，用于治疗由端粒酶活性介导的疾病或病症，例如癌症的治疗。还公开了用于检测或筛选端粒酶活性抑制剂的方法。