4-[6-羟基-4-甲氧基-5-(3-甲基丁-2-烯-1-基)-1-苯并呋喃-2-基]苯-1,3-二酚 | 118524-14-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 中文名称: 4-[6-羟基-4-甲氧基-5-(3-甲基丁-2-烯-1-基)-1-苯并呋喃-2-基]苯-1,3-二酚
• 英文名称: Licocoumarone
• 英文别名: 4-[6-hydroxy-4-methoxy-5-(3-methylbut-2-enyl)-1-benzofuran-2-yl]benzene-1,3-diol
• CAS: 118524-14-4
• 化学式: C₂₀H₂₀O₅
• 分子量: 340.376
• InChiKey: CNPMAFLUEHEXRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  83.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-[6-羟基-4-甲氧基-5-(3-甲基丁-2-烯-1-基)-1-苯并呋喃-2-基]苯-1,3-二酚 、 重氮甲烷 生成 2-(2',4'-Dimethoxyphenyl)-4,6-dimethoxy-5-(γ,γ-dimethylallyl)-coumaron
  参考文献：
  名称：

  甘草的抗氧化剂和抗菌成分：一种新的苯并呋喃衍生物的分离和结构解析。

  摘要：

  A new 2-arylbenzofuran derivative named licocoumarone (IIa) was isolated from commercially available xibei licorice (seihoku kanzo) along with a known 3-arylcoumarin derivative, glycycoumarin (Ia), and the structure of IIa was elucidated as 2-(2, 4-dihydroxyphenyl)-6-hydroxy-4-methoxy-5-(3-methyl-2-butenyl)coumarone on the basis of spectroscopic and chemical studies. Both Ia and IIa exhibited antimicrobial activities, whereas only IIa had antioxidant activity.

  DOI：

  10.1248/cpb.36.3474

文献信息

• Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
  申请人：Scaramuzzino, Giovanni

  公开号：EP1336602A1

  公开（公告）日：2003-08-20

  New pharmaceutical compounds of general formula (I): F-(X)q where q is an integer from 1 to 5, preferably 1; -F is chosen among drugs described in the text, -X is chosen among 4 groups -M, -T, -V and -Y as described in the text. The compounds of general formula (I) are nitrate prodrugs which can release nitric oxide in vivo in a controlled and selective way and without hypotensive side effects and for this reason they are useful for the preparation of medicines for prevention and treatment of inflammatory, ischemic, degenerative and proliferative diseases of musculoskeletal, tegumental, respiratory, gastrointestinal, genito-urinary and central nervous systems.

  通式（I）的新药物化合物：F-（X）q，其中q是1到5的整数，最好是1；-F是在文本中描述的药物中选择的，-X是在文本中描述的4个组-M，-T，-V和-Y中选择的。通式（I）的化合物是硝酸盐前药，可以在体内以受控和选择性的方式释放一氧化氮，而不会产生降压副作用，因此它们非常适用于制备用于预防和治疗肌肉骨骼，皮肤，呼吸，消化，泌尿和中枢神经系统的炎症，缺血，退行性和增生性疾病的药物。
• COMPOSITION CONTAINING LICORICE-DERIVED POLYPHENOL
  申请人：Kaneka Corporation

  公开号：EP2163252A1

  公开（公告）日：2010-03-17

  A composition containing a licorice polyphenol and other active ingredient (antioxidant ingredient, polyphenol other than licorice polyphenol or a component relating to lipid absorption or metabolism) is highly safe, can be produced easily, and can be utilized for foods and drinks such as health food, food with health claims (specified health food, food with nutrient function claims) and the like, pharmaceutical products, quasi-drugs, cosmetics and the like. In addition, since the composition has a body fat accumulation suppressing effect, a body fat decomposition promoting effect or energy production promoting effect, it is useful for the treatment of obesity, metabolic syndrome and the like.

  含有甘草多酚和其他活性成分（抗氧化成分、甘草多酚以外的多酚或与脂质吸收或代谢有关的成分）的组合物安全性高，易于生产，可用于保健食品、健康声称食品（指定保健食品、营养功能声称食品）等食品和饮料、医药产品、准药品、化妆品等。此外，由于该组合物具有抑制体内脂肪堆积的效果、促进体内脂肪分解的效果或促进能量产生的效果，因此可用于治疗肥胖症、代谢综合征等。
• METHOD OF PRODUCING REDUCED COENZYME Q10 AND METHOD OF STABILIZING THE SAME
  申请人：Kaneka Corporation

  公开号：EP2186789A1

  公开（公告）日：2010-05-19

  The present invention provides a stabilization method of reduced coenzyme Q10 useful as food, food with nutrient function claims, food for specified health uses, nutritional supplement, nutritional supplement, animal drugs, drinks, feeds, cosmetics, pharmaceutical products, therapeutic drugs, prophylactic drugs and the like, as well as a stabilized composition. Furthermore, it provides a convenient production method of reduced coenzyme Q10 using oxidized coenzyme Q10 as a starting material. In the present invention, oxidation of reduced coenzyme Q10 can be suppressed, and reduced coenzyme Q10 can be stably maintained by the co-presence of a licorice hydrophobic extract and reduced coenzyme Q10. In addition, reduced coenzyme Q10 can be produced by the co-presence of oxidized coenzyme Q10 and a licorice hydrophobic extract.

  本发明提供了一种还原型辅酶 Q10 的稳定化方法，可用于食品、声称具有营养功能的食品、特定保健用途食品、营养补充剂、营养补充品、动物药品、饮料、饲料、化妆品、医药产品、治疗药物、预防药物等，以及稳定化组合物。此外，本发明还提供了一种以氧化辅酶 Q10 为起始原料的还原型辅酶 Q10 的便捷生产方法。在本发明中，通过甘草疏水提取物和还原型辅酶Q10的共存，可以抑制还原型辅酶Q10的氧化，并稳定地维持还原型辅酶Q10。此外，氧化型辅酶 Q10 和甘草疏水提取物共存可产生还原型辅酶 Q10。
• COMPOSITION FOR PREVENTING OR TREATING ROTAVIRUS INFECTION CONTAINING LICORICE EXTRACT
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP2535056A2

  公开（公告）日：2012-12-19

  The present invention relates to a composition for preventing or treating rotavirus infection, comprising a licorice extract, fractions thereof or compounds separated therefrom. The licorice extract, fractions thereof or compounds separated therefrom have anti-rotavirus effects and exhibit not only virucidal effects against various rotaviruses, but also the effect of inhibiting the cytopathic effect of rotaviruses. Thus, the composition can be effectively used for the prevention or treatment of rotavirus infection.

  本发明涉及一种用于预防或治疗轮状病毒感染的组合物，该组合物由甘草提取物、其馏分或从中分离出的化合物组成。甘草提取物、其馏分或从中分离出的化合物具有抗轮状病毒的作用，不仅对各种轮状病毒具有杀病毒作用，还具有抑制轮状病毒细胞病理效应的作用。因此，该组合物可有效用于预防或治疗轮状病毒感染。
• Process for producing fat composition containing hydrophobic components of glycyrrhiza
  申请人：Ikehara Toshinori

  公开号：US20050118289A1

  公开（公告）日：2005-06-02

  In the present invention, an oil and fat composition containing 10% by weight or more of a specific fat-soluble polyhydric fatty acid ester, in particular, a glycerol fatty acid ester, is used as a solvent for extracting hydrophobic components from licorice. Consequently, it is possible to reduce the production costs for hydrophobic components of licorice which have excellent effects as food and drink, such as health food and food with health claims (food for specified health uses and food with nutrient function claims), pharmaceutical products, etc. It is also possible to improve the stability and handling properties of the resulting composition.

  在本发明中，一种油脂组合物含有 10%（按重量计）或更多的特定脂溶性多氢脂 肪酸酯，特别是甘油脂肪酸酯，用作从甘草中提取疏水成分的溶剂。因此，可以降低甘草疏水性成分的生产成本，这些疏水性成分作为食品和饮料，如保健食品和保健声称食品（特定保健用途食品和营养功能声称食品）、药品等，具有很好的效果。此外，还可以提高所得成分的稳定性和处理性能。