4-[[(1,1-二甲基乙基)氧化亚氨基]甲基]-1,3-苯二磺酸二钠

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-[[(1,1-二甲基乙基)氧化亚氨基]甲基]-1,3-苯二磺酸二钠
• 中文别名: 神经保护药物NXY059；神经保护药物 NXY 059；神经保护药物 NXY 59
• 英文名称: disodium;4-[[tert-butyl(oxido)azaniumylidene]methyl]benzene-1,3-disulfonate
• 化学式: C11H13NNa2O7S2
• 分子量: 381.3
• InChiKey: XLZOVRYBVCMCGL-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -5.77
• 重原子数：
  23
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  160
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  disodium;4-formylbenzene-1,3-disulfonate 、 N-叔丁基羟胺 在 disodium;4-formylbenzene-1,3-disulfonate 作用下， 以78.8的产率得到4-[[(1,1-二甲基乙基)氧化亚氨基]甲基]-1,3-苯二磺酸二钠
  参考文献：
  名称：

  [EN] NOVEL SALTS OF N-TERT-BUTYLHYDROXYLAMINE
  [FR] NOUVEAUX SELS DE N-TERT-BUTYLHYDROXYLAMINE

  摘要：

  本发明公开了N-叔丁基羟胺与低级羧酸的新型盐，以及其制备方法。这些盐具有优良的性质，使它们在合成中有用。

  公开号：

  WO2000002848A1

文献信息

• 2,4-disulfonyl phenyl butyl nitrone, its salts, and their use as
  申请人：Oklahoma Medical Research Foundation

  公开号：US05488145A1

  公开（公告）日：1996-01-30

  2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss.

  本文披露了2,4-二磺酰基.alpha.-苯基-叔丁基亚硝基甲烷及其药学上可接受的盐。这些物质可用作口服或静脉注射的药物治疗剂，用于治疗因中枢神经系统氧化而引起的急性中风或逐渐中枢神经系统氧化的患者，后者可能表现为进行性中枢神经系统功能丧失。
• 2,4-disulfo phenyl butyl nitrone, its salts and their use as
  申请人：Oklahoma Medical Research Foundation

  公开号：US05780510A1

  公开（公告）日：1998-07-14

  2,4-disulfonyl .alpha.-phenyl-tert-butyl nitrone and its pharmaceutically acceptable salts are disclosed. These materials are useful as pharmaceutical agents for oral or parenteral, e.g. intravenous administration to patients suffering from acute central nervous system oxidation as occurs in a stroke or from gradual central nervous system oxidation which can exhibit itself as progressive central nervous system function loss. The materials are also used to ameliorate the side effects of oxidative-damage causing antineoplastic disease treatments.

  本文介绍了2,4-二磺酰基-α-苯基-叔丁基亚硝基甲烷及其药学上可接受的盐。这些物质可用作口服或静脉注射等途径的药物，用于治疗急性中枢神经系统氧化（如中风）或逐渐出现的中枢神经系统氧化，后者可表现为进行性中枢神经系统功能丧失。这些物质还可用于缓解引起氧化损伤的抗肿瘤治疗的副作用。
• Process for the preparation of alkali metal and alkaline earth salts of
  申请人：Hoechst Aktiengesellschaft

  公开号：US04710322A1

  公开（公告）日：1987-12-01

  The invention consists in an improved process for the preparation of salts of benzaldehyde-2,4-disulfonic acid from 2,4-dichlorobenzaldehyde. In the process 2,4-di-chlorobenzaldehyde is reacted with an aqueous solution of an alkali metal or alkaline earth sulfite and/or hydrogensulfite for a reaction time of less than 7 hours at 140.degree.-180.degree. C. to form the corresponding salt of benzaldehyde-2,4-disulfonic acid with high yield. The product has application in the electroplating industry and in the preparation triphenylmethane dyestuffs.

  本发明涉及从2,4-二氯苯甲醛制备苯甲醛-2,4-二磺酸盐的改进工艺。在该工艺中，将2,4-二氯苯甲醛与碱金属或碱土金属亚硫酸盐和/或氢亚硫酸盐的水溶液反应，反应时间小于7小时，反应温度为140-180°C，高产率地形成相应的苯甲醛-2,4-二磺酸盐。该产品在电镀工业和三苯甲烷染料的制备中具有应用。
• [EN] NOVEL PROCESS FOR THE PREPARATION OF alpha -(2-4-DISULFOPHENYL)-N-TERT-BUTYLNITRONE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF<br/>[FR] NOUVEAU PROCEDE DE PREPARATION DE alpha -(2-4-DISULFOPHENYL)-N-TERT-BUTYLNITRONE ET DE SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CELLE-CI
  申请人：ASTRAZENECA AB

  公开号：WO2001051460A1

  公开（公告）日：2001-07-19

  A process for the preparation of α-(2-4-disulfophenyl)-N-tert-butylnitrone and pharmaceutically acceptable salts thereof by the reaction of the corresponding disulfophenyl aldehyde with N-tert-butylhydroxylammonium acetate is disclosed.

  本发明公开了一种制备α-(2-4-二磺酰基苯基)-N-叔丁基亚硝基甲酸盐及其药学上可接受的盐的方法，该方法是通过将相应的二磺酰基苯醛与N-叔丁基羟胺醋酸盐反应而得到的。
• J. Labelled Cpd. Radiopharm. 2000, 43, 1265-1273
  作者：

  DOI：——

  日期：——