3-(4,5-dichloroimidazol-1-yl)propylamine | 733756-65-5

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 芳基卤化物
• 英文名称: 3-(4,5-dichloroimidazol-1-yl)propylamine
• 英文别名: 4,5-dichloro-1-(3-aminopropyl)imidazole；3-(4,5-dichloroimidazolyl)propylamine；3-(4,5-dichloroimidazol-1-yl)propan-1-amine
• CAS: 733756-65-5
• 化学式: C₆H₉Cl₂N₃
• 分子量: 194.064
• InChiKey: MIIXDGCPVLDIOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-chloro-2-phenylaminopyrimidine-4-carboxylic acid 、 3-(4,5-dichloroimidazol-1-yl)propylamine 在 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 24.0h， 以60%的产率得到5-chloro-2-phenylaminopyrimidine-4-carboxylic acid [3-(4,5-dichloroimidazol-1-yl)propyl]amide
  参考文献：
  名称：

  WO2007/73117

  摘要：

  公开号：

文献信息

• [EN] GLYCOGEN SYNTHASE KINASE 3BETA INHIBITOR, COMPOSITION AND PROCESS FOR THE PREPARATION THEREOF<br/>[FR] INHIBITEUR DE GLYCOGENE SYNTHASE KINASE 3 DOLLAR G(B), COMPOSITION ET PROCEDE DE PREPARATION ASSOCIE
  申请人：CRYSTALGENOMICS INC

  公开号：WO2004065370A1

  公开（公告）日：2004-08-05

  Novel compounds having hydroxybenzoimidazole carboxylic amide are useful for inhibiting glycogen synthase kinase 3β (GSK-3β).

  具有羟基苯并咪唑羧酰胺的新化合物对抑制糖原合成酶激酶3β（GSK-3β）具有用处。
• Glycogen synthase kinase 3beta inhibitor, composition and process for the preparation thereof
  申请人：Cho Myung Joong

  公开号：US20060079521A1

  公开（公告）日：2006-04-13

  Novel compounds having hydroxybenzoimidazole carboxylic amide are useful for inhibiting glycogen synthase kinase 3β (GSK-3β).

  含有羟基苯并咪唑羧酰胺的新化合物可用于抑制糖原合酶激酶3β (GSK-3β)。
• Aminopyrimidine Derivatives Inhibiting Protein Kinase Activity, Method For The Preparation Thereof And Pharmaceutical Composition Containing Same
  申请人：Park Boonsaeng

  公开号：US20090227612A1

  公开（公告）日：2009-09-10

  A compound of formula 1 efficiently inhibits several protein kinases including glycogen synthase kinase 3 (GSK), aurora kinase, extracellular signal-regulated kinase (ERK), protein kinase B (AKT), and the likes, to control signal transductions involved in variable disorders such as diabetes, obesity, dementia, cancer, and inflammation.

  化合物1的公式能有效抑制多种蛋白激酶，包括糖原合成酶激酶3（GSK）、极化激酶、细胞外信号调节激酶（ERK）、蛋白激酶B（AKT）等，以控制涉及不同疾病的信号转导，如糖尿病、肥胖、痴呆、癌症和炎症。
• Glycogen synthase kinase 3β inhibitor, composition and process for the preparation thereof
  申请人：Crystalgenomics, Inc.

  公开号：US07179832B2

  公开（公告）日：2007-02-20

  Novel compounds having hydroxybenzoimidazole carboxylic amide are useful for inhibiting glycogen synthase kinase 3β(GSK-3β).

  含有羟基苯并咪唑羧酰胺的新化合物可用于抑制糖原合成酶激酶3β（GSK-3β）。
• Structure–activity relationship of the 7-hydroxy benzimidazole analogs as glycogen synthase kinase 3β inhibitor
  作者：Seung-Chul Lee、Dongkyu Shin、Joong Myung Cho、Sunggu Ro、Young-Ger Suh

  DOI：10.1016/j.bmcl.2012.01.065

  日期：2012.3

  Design, synthesis and the GSK3 beta inhibitory activities of the 7-hydroxy benzimidazole analogs are described. The solid-phase synthetic route was also developed for preparation of the analogs consisting of the novel ATP competitive scaffold. In addition, the structure-activity relationship of the 7-hydroxy benzimidazole analogs and their biological activities are reported. (c) 2012 Elsevier Ltd. All rights reserved.