1-(2,2-dibromo-1,1-dimethoxyethyl)-4-fluorobenzene | 1575824-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2,2-dibromo-1,1-dimethoxyethyl)-4-fluorobenzene
• 英文别名: 1-(2,2-Dibromo-1,1-dimethoxyethyl)-4-fluorobenzene
• CAS: 1575824-37-1
• 化学式: C₁₀H₁₁Br₂FO₂
• 分子量: 342.003
• InChiKey: BTFIERHHRFKLDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲醇 、 4-氟苯乙炔 在 dibromamine-T 作用下， 反应 0.08h， 以79%的产率得到1-(2,2-dibromo-1,1-dimethoxyethyl)-4-fluorobenzene
  参考文献：
  名称：

  Facile generation of α,α-dibromodimethyl ketals from alkynes using TsNBr2

  摘要：

  TsNBr2 reacts with alkyne in the presence of methanol to form alpha,alpha-dibromodimethyl ketals instantaneously. The reaction proceeds smoothly at room temperature without using any other catalyst. The one step reaction can be carried out with both aromatic and aliphatic alkynes in excellent yield. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.123

文献信息

• Facile generation of α,α-dibromodimethyl ketals from alkynes using TsNBr2
  作者：Kamal Krishna Rajbongshi、Prodeep Phukan

  DOI：10.1016/j.tetlet.2014.01.123

  日期：2014.3

  TsNBr2 reacts with alkyne in the presence of methanol to form alpha,alpha-dibromodimethyl ketals instantaneously. The reaction proceeds smoothly at room temperature without using any other catalyst. The one step reaction can be carried out with both aromatic and aliphatic alkynes in excellent yield. (C) 2014 Elsevier Ltd. All rights reserved.
• Iron(III) catalyzed halo-functionalization of alkynes
  作者：Bryant Catano、John Lee、Claudia Kim、David Farrell、Jeffrey L. Petersen、Yalan Xing

  DOI：10.1016/j.tetlet.2015.05.039

  日期：2015.7

  Aromatic and aliphatic alkynes can be halo-functionalized to alpha,alpha-dihalodimethyl ketals catalyzed by FeCl3 in excellent yields. MeOH is used as a nucleophilic solvent and N-halosuccinimide as the halogen source for this efficient transformation. The resulting alpha,alpha-dibromodimethyl ketals can be converted to the corresponding alpha,alpha-dibromoketones by treatment with 8% FeCl3 in silica gel. (C) 2015 Elsevier Ltd. All rights reserved.