ethyl (2S)-2-[(1R)-1-(4-hydroxyphenyl)ethoxy]propanoate | 1210825-35-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: ethyl (2S)-2-[(1R)-1-(4-hydroxyphenyl)ethoxy]propanoate
• CAS: 1210825-35-6
• 化学式: C₁₃H₁₈O₄
• 分子量: 238.284
• InChiKey: HLLYCUZPQNDJIQ-ZJUUUORDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  L(-)-乳酸乙酯 、 (+)-4-(1'-methoxyethyl)phenol 在 对甲苯磺酸 作用下， 生成 ethyl (2S)-2-[(1S)-1-(4-hydroxyphenyl)ethoxy]propanoate 、 ethyl (2S)-2-[(1R)-1-(4-hydroxyphenyl)ethoxy]propanoate
  参考文献：
  名称：

  [EN] NEW PROPANOATES AND PROCESSES FOR PREPARING THE SAME
  [FR] NOUVEAUX PROPANOATES ET LEURS PROCÉDÉS DE PRÉPARATION

  摘要：

  一种制备丙酸酯的方法，包括以下步骤：(i)提供含有4-羟基苯甲基碳醇的甲醇溶液，(ii)将该溶液在酸催化的位移反应下，在适当的温度和压力条件下足够长的时间内转化几乎全部的碳醇为溶液中的4-羟基苯甲基碳醇甲醚，(iii)用第二溶剂取代所述醚所含甲醇的溶液，(iv)在适当的温度和压力条件下，用适当的酸催化剂反应所述醚含乙酸乙酯溶液足够长的时间，以形成所述丙酸酯。按照上述方法制备的新物质组成包括丙酸酯，在电子化学品市场上具有应用，例如在光刻胶组合物中。

  公开号：

  WO2010024841A1

文献信息

• NEW PROPANOATES AND PROCESSES FOR PREPARING THE SAME
  申请人：DuPont Electronic Polymers L.P.

  公开号：EP2315739B1

  公开（公告）日：2014-11-12
• New propanoates and processes for preparing the same
  申请人：Sheehan Michael T.

  公开号：US20100047714A1

  公开（公告）日：2010-02-25

  A process for preparing proponates which comprises the steps of (i) supplying a solution of methanol containing 4-hydroxyphenylmethylcarbinol, (ii) subjecting said solution to an acid catalyzed displacement reaction for a sufficient period of time and under suitable conditions of temperature and pressure to convert substantially all of said carbinol to 4-hydroxyphenylmethylcarbinol methyl ether in solution, (iii) replacing the methanol in said ether containing solution with a second solvent and (iv) reacting the ether containing ethyl lactate solution with a suitable acid catalyst for a sufficient period of time and under suitable conditions of temperature and pressure to form said propanoates. New compositions of matter which comprise the propanoates, prepared in the above manner, have application in the electronic chemicals market such as in a photoresist composition.
• US8163464B2
  申请人：——

  公开号：US8163464B2

  公开（公告）日：2012-04-24
• [EN] NEW PROPANOATES AND PROCESSES FOR PREPARING THE SAME<br/>[FR] NOUVEAUX PROPANOATES ET LEURS PROCÉDÉS DE PRÉPARATION
  申请人：DUPONT ELECTRONIC POLYMERS L P

  公开号：WO2010024841A1

  公开（公告）日：2010-03-04

  A process for preparing proponates which comprises the steps of (i) supplying a solution of methanol containing 4-hydroxyphenylmethylcarbinol, (ii) subjecting said solution to an acid catalyzed displacement reaction for a sufficient period of time and under suitable conditions of temperature and pressure to convert substantially all of said carbinol to 4-hydroxyphenylmethylcarbinol methyl ether in solution, (iii) replacing the methanol in said ether containing solution with a second solvent and (iv) reacting the ether containing ethyl lactate solution with a suitable acid catalyst for a sufficient period of time and under suitable conditions of temperature and pressure to form said propanoates. New compositions of matter which comprise the propanoates, prepared in the above manner, have application in the electronic chemicals market such as in a photoresist composition.

  一种制备丙酸酯的方法，包括以下步骤：(i)提供含有4-羟基苯甲基碳醇的甲醇溶液，(ii)将该溶液在酸催化的位移反应下，在适当的温度和压力条件下足够长的时间内转化几乎全部的碳醇为溶液中的4-羟基苯甲基碳醇甲醚，(iii)用第二溶剂取代所述醚所含甲醇的溶液，(iv)在适当的温度和压力条件下，用适当的酸催化剂反应所述醚含乙酸乙酯溶液足够长的时间，以形成所述丙酸酯。按照上述方法制备的新物质组成包括丙酸酯，在电子化学品市场上具有应用，例如在光刻胶组合物中。