5-benzylimidazo<4,5-c>pyridine | 105942-38-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 5-benzylimidazo<4,5-c>pyridine
• 英文别名: 5-Benzylimidazo[4,5-c]pyridine
• CAS: 105942-38-9
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: ATXLHMZMMKUPNH-UHFFFAOYSA-N

物化性质

• 熔点：
  174-176 °C(Solv: benzene (71-43-2))
• 沸点：
  321.1±52.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30.7
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  5-benzylimidazo<4,5-c>pyridine 生成 1-benzyl-1H-imidazo[4,5-c]pyridine
  参考文献：
  名称：

  YUTILOV, YU. M.;MIXAJLOVA, L. E.;IGNATENKO, A. G., ZH. ORGAN. XIMII, 1986, 22, N 2, 445-446

  摘要：

  DOI：
• 作为产物：
  描述：

  5-benzylimidazo<4,5-c>pyridinium chloride 在 conc. alkali 作用下， 以89.3%的产率得到5-benzylimidazo<4,5-c>pyridine
  参考文献：
  名称：

  Yutilov, Yu. M.; Mikhailova, L. E.; Ignatenko, A. G., Journal of Organic Chemistry USSR (English Translation), 1986, vol. 22, p. 394 - 395

  摘要：

  DOI：

文献信息

• Viral inhibitors
  申请人：Neyts Johan

  公开号：US20050239821A1

  公开（公告）日：2005-10-27

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine derivative having the general formula (Z): (formula). The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包括至少一种具有通式（Z）的咪唑并[4,5-c]吡啶衍生物作为活性成分。本发明还涉及根据上述通式制备化合物的方法以及它们作为药物或用于治疗或预防病毒感染的用途。
• Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment
  申请人：Bondy S. Steven

  公开号：US20050222198A1

  公开（公告）日：2005-10-06

  The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (A): wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及制备用于治疗或预防病毒感染的药物组合物，其包含至少一种具有通式（A）的咪唑[4,5-c]吡啶前药作为活性成分，其中取代基在规范中描述。本发明还涉及根据上述通式制备和筛选化合物的过程，以及它们在治疗或预防病毒感染中的用途。
• Imidazo 4,5-C Pyridine Compounds and Methods of Antiviral Treatment
  申请人：Bondy S. Steven

  公开号：US20070244148A1

  公开（公告）日：2007-10-18

  The present invention relates to a pharmaceutical composition for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general formula (Z): The invention also relates to processes for the preparation of compounds according to the invention having above mentioned general formula and their use as a medicine or to treat or prevent viral infections.

  本发明涉及一种用于治疗或预防病毒感染的药物组合物，其包含至少一种具有以下通式（Z）的咪唑[4,5-c]吡啶前药作为活性成分：本发明还涉及制备符合上述通式的化合物的方法以及它们作为药物或用于治疗或预防病毒感染的用途。
• VIRAL INHIBITORS
  申请人：NEYTS Johan

  公开号：US20100004281A1

  公开（公告）日：2010-01-07

  The present invention relates to imidazo[4,5-c]pyridine compounds and pharmaceutical compositions for the treatment or prevention of viral infections, wherein the imidazo[4,5-c]pyridine compounds have the formula:

  本发明涉及咪唑并[4,5-c]吡啶化合物和制备其药学组合物用于治疗或预防病毒感染，其中咪唑并[4,5-c]吡啶化合物的化学式为：
• IMIDAZO[4,5-c]PYRIDINE COMPOUNDS AND METHODS OF ANTIVIRAL TREATMENT
  申请人：Bondy Steven S.

  公开号：US20100028301A1

  公开（公告）日：2010-02-04

  The present invention relates to pharmaceutical compositions for the treatment or prevention of viral infections comprising as an active principle at least one imidazo[4,5-c]pyridine prodrug having the general Formula (A) wherein the substituents are described in the specification. The invention also relates to processes for the preparation and screening of compounds according to the invention having above mentioned general Formula and their use in the treatment or prophylaxis of viral infections.

  本发明涉及一种制备用于治疗或预防病毒感染的药物组合物，其包含至少一种咪唑并[4,5-c]吡啶前药作为活性成分，其通式为（A），其中取代基在规范中描述。该发明还涉及根据上述通式制备和筛选化合物的方法以及它们在治疗或预防病毒感染中的应用。