2-[2-[(2-cyclohexyl-ethyl)-(4-trifluoromethyl-phenyl)-amino]-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-4-methyl-pentanoic acid | 1206476-72-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-[2-[(2-cyclohexyl-ethyl)-(4-trifluoromethyl-phenyl)-amino]-6-(4-trifluoromethyl-phenyl)-pyridin-4-yl]-4-methyl-pentanoic acid
• 英文别名: 2-[2-[N-(2-cyclohexylethyl)-4-(trifluoromethyl)anilino]-6-[4-(trifluoromethyl)phenyl]pyridin-4-yl]-4-methylpentanoic acid
• CAS: 1206476-72-3
• 化学式: C₃₃H₃₆F₆N₂O₂
• 分子量: 606.651
• InChiKey: REJFNZBFXUSJLO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.6
• 重原子数：
  43
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• PYRIDINYL MODULATORS OF gamma-SECRETASE
  申请人：Lu Tianbao

  公开号：US20100022583A1

  公开（公告）日：2010-01-28

  The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R 1 R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , and R 9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.

  本发明涉及如下所示的Formula I化合物，其中A、X、R1、R2、R3、R4、R5、R6、R7、R8和R9的定义在说明书中提供。Formula I化合物对于治疗与γ-分泌酶活性相关的疾病，包括阿尔茨海默病，具有用处。
• PYRIDINYL MODULATORS OF y-SECRETASE
  申请人：Janssen Pharmaceutica, N.V.

  公开号：EP2321278A2

  公开（公告）日：2011-05-18
• US7968725B2
  申请人：——

  公开号：US7968725B2

  公开（公告）日：2011-06-28
• [EN] PYRIDINYL MODULATORS OF ?-SECRETASE<br/>[FR] MODULATEURS PYRIDINYLIQUE DE ?-SÉCRÉTASE
  申请人：JANSSEN PHARMACEUTICA NV

  公开号：WO2010011626A2

  公开（公告）日：2010-01-28

  The present invention relates to compounds of Formula I as shown below, wherein the definitions of A, X, R1 R2, R3, R4, R5, R6, R7, R8, and R9 are provided in the specification. Compounds of Formula I are useful for the treatment of diseases associated with γ-secretase activity, including Alzheimer's disease.