S(R)-N-[(1R)-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)(phenyl)methyl]-2-methylpropane-2-sulfinamide | 1239471-41-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: S(R)-N-[(1R)-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)(phenyl)methyl]-2-methylpropane-2-sulfinamide
• CAS: 1239471-41-0
• 化学式: C₃₁H₄₁NO₃SSi
• 分子量: 535.823
• InChiKey: IAHSDIBTNCAMFA-LNCBLLTNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.52
• 重原子数：
  37.0
• 可旋转键数：
  11.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  47.56
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  S(R)-N-[(1R)-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)(phenyl)methyl]-2-methylpropane-2-sulfinamide 在 盐酸 作用下， 以 甲醇 为溶剂， 反应 18.0h， 生成
  参考文献：
  名称：

  Stereocontrolled Synthesis of 2-Substituted-1,3-Azasilaheterocycles

  摘要：

  Chiral alpha-silylsulfinamides, prepared by the treatment of an alkyldiphenylsilane with lithium followed by its addition to a sulfinimine, can be applied to the synthesis of 1,3-azasilaheterocycles as derivatives of cyclic alkaloids. This synthetic route, which involves intramolecular substitution of an amino alcohol or cyclization of an amino acid promoted by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), represents a convenient means for accessing these silicon-containing heterocycles.

  DOI：

  10.1021/ol101379t
• 作为产物：
  描述：

  (diphenyl)(3-((tetrahydro-2H-pyran-2-yl)oxy)propyl)silane 、 (R,E)-2-methyl-N-(phenylmethylene)-2-propanesulfinamide 在 lithium 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以68%的产率得到S(R)-N-[(1R)-(diphenyl(3-(tetrahydro-2H-pyran-2-yloxy)propyl)silyl)(phenyl)methyl]-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Stereocontrolled Synthesis of 2-Substituted-1,3-Azasilaheterocycles

  摘要：

  Chiral alpha-silylsulfinamides, prepared by the treatment of an alkyldiphenylsilane with lithium followed by its addition to a sulfinimine, can be applied to the synthesis of 1,3-azasilaheterocycles as derivatives of cyclic alkaloids. This synthetic route, which involves intramolecular substitution of an amino alcohol or cyclization of an amino acid promoted by 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC), represents a convenient means for accessing these silicon-containing heterocycles.

  DOI：

  10.1021/ol101379t