N-(3-Chloro-4-methoxy-phenyl)-N'-cycloheptyl-6-(1-ethyl-piperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine | 866768-69-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-Chloro-4-methoxy-phenyl)-N'-cycloheptyl-6-(1-ethyl-piperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine
• 英文别名: N-(3-chloro-4-methoxyphenyl)-N'-cycloheptyl-6-(1-ethylpiperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine；4-N-(3-chloro-4-methoxyphenyl)-2-N-cycloheptyl-6-(1-ethylpiperidin-3-yl)oxy-1,3,5-triazine-2,4-diamine
• CAS: 866768-69-6
• 化学式: C₂₄H₃₅ClN₆O₂
• 分子量: 475.034
• InChiKey: OTAPNRQAOHGPFK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  84.4
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-乙基-3-羟基哌啶 、 6-chloro-N2-(3-chloro-4-methoxy-phenyl)-N4-cycloheptyl-[1,3,5]triazine-2,4-diamine 在 sodium hydroxide 作用下， 以 苯 为溶剂， 反应 14.0h， 以81%的产率得到N-(3-Chloro-4-methoxy-phenyl)-N'-cycloheptyl-6-(1-ethyl-piperidin-3-yloxy)-[1,3,5]triazine-2,4-diamine
  参考文献：
  名称：

  Triazine compounds and their analogs, compositions, and methods

  摘要：

  本发明涉及三嗪化合物及其类似物和衍生物，以及包含这些化合物的方法和组合物。本发明的化合物和组合物可用于治疗由炎症反应引起的病理生理条件，抑制或阻断糖化蛋白诱导内皮细胞中与信号相关的炎症反应，抑制平滑肌增殖，治疗以平滑肌增殖为特征的血管闭塞性疾病，如再狭窄和动脉粥样硬化等。

  公开号：

  US20050227983A1

文献信息

• Luminogenic and fluorogenic compounds and methods to detect molecules or conditions
  申请人：Cali James J.

  公开号：US20080299593A1

  公开（公告）日：2008-12-04

  A method to detect the presence or amount of at least one molecule in a sample which employs a derivative of luciferin or a derivative of a fluorophore is provided. Compounds and compositions for carrying out the methods of the invention are also provided.

  本发明提供了一种检测样品中至少一种分子存在或数量的方法，该方法采用了路西非酮衍生物或荧光染料衍生物。还提供了用于执行本发明方法的化合物和组合物。
• US7335770B2
  申请人：——

  公开号：US7335770B2

  公开（公告）日：2008-02-26
• US8476450B2
  申请人：——

  公开号：US8476450B2

  公开（公告）日：2013-07-02
• [EN] TRIAZINE COMPOUNDS AND THEIR ANALOGS, COMPOSITIONS, AND METHODS<br/>[FR] COMPOSES A BASE DE TRIAZINE ET LEURS ANALOGUES, COMPOSITIONS, ET PROCEDES
  申请人：REDDY US THERAPEUTICS INC

  公开号：WO2005103015A1

  公开（公告）日：2005-11-03

  The present invention relates to triazine compounds and their analogs and derivatives, and methods and compositions comprising these compounds. The compounds and compositions of this invention are useful for, among other things, treating pathophysiological conditions arising from inflammatory responses, inhibiting or blocking glycated protein produced induction of the signaling-associated inflammatory response in endothelial cells, inhibiting smooth muscle proliferation, treating vascular occlusive conditions characterized by smooth muscle proliferation such as restenosis and atherosclerosis, and the like.