2-Benzyl-6-methylanilin | 60287-75-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-Benzyl-6-methylanilin
• 英文别名: 2-Benzyl-6-methylaniline
• CAS: 60287-75-4
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: OMQBGJIIVSUOML-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  甲酸 、 2-Benzyl-6-methylanilin 生成 N-(2-苄基-6-甲基苯基)甲酰胺
  参考文献：
  名称：

  Wardrop,A.W.H. et al., Journal of the Chemical Society. Perkin transactions I, 1976, p. 1279 - 1285

  摘要：

  DOI：
• 作为产物：
  描述：

  (2-amino-3-methylphenyl)(phenyl)methanone 在 lithium aluminium tetrahydride 作用下， 以 乙醚 为溶剂， 生成 2-Benzyl-6-methylanilin
  参考文献：
  名称：

  Wardrop,A.W.H. et al., Journal of the Chemical Society. Perkin transactions I, 1976, p. 1279 - 1285

  摘要：

  DOI：

文献信息

• Arylpiperidine and arylpiperazine derivatives and medicament containing
  申请人：Suntory Limited

  公开号：US05723475A1

  公开（公告）日：1998-03-03

  The compound of the formula (I) or its salt or a medicament containing the same ##STR1## wherein, A and B represent a carbonyl group or sulfonyl group, m and p are different and represent 0 or 1, R.sup.1 and R.sup.2 may be the same or different from each other and represent a hydrogen atom, an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted aralkyl group, an unsubstituted or substituted heterocyclic group containing nitrogen or an unsubstituted or substituted heterocyclic group containing oxygen, or R.sup.1 and R.sup.2, taken together with the nitrogen atom to which they are linked, may form an unsubstituted or substituted heterocyclic group, provided that when B is a sulfonyl group, R.sup.2 does not represent a hydrogen atom, n is an integer of 1 to 6, X represents a methylene group or an oxygen atom, E and Y may be the same or different from each other and represent a hydrogen atom, a halogen atom, an alkoxy group, or an alkyl group which may be substituted by a halogen atom the dotted line shows the presence or absence of a bond, when said dotted line shows the presence of a bond, Z represents a carbon atom, and when said dotted line shows the absence of a bond, Z represents CH or a nitrogen atom.

  化合物的公式(I)或其盐或含有该化合物的药物，其中，A和B代表羰基或磺酰基，m和p不同且代表0或1，R.sup.1和R.sup.2可能相同或不同，分别代表氢原子，未取代或取代的烷基，未取代或取代的芳基，未取代或取代的芳基烷基，含氮的未取代或取代的杂环基或含氧的未取代或取代的杂环基，或R.sup.1和R.sup.2与它们连接的氮原子一起可能形成未取代或取代的杂环基，但当B为磺酰基时，R.sup.2不代表氢原子，n为1至6的整数，X代表亚甲基或氧原子，E和Y可能相同或不同，分别代表氢原子，卤素原子，烷氧基或可以被卤素原子取代的烷基，虚线表示键的存在或不存在，当虚线表示键的存在时，Z代表碳原子，当虚线表示键的不存在时，Z代表CH或氮原子。
• ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME
  申请人：SUNTORY LIMITED

  公开号：EP0757986A1

  公开（公告）日：1997-02-12

  The compound of the formula (I) or its salt or a medicament containing the same wherein, A and B represent a carbonyl group or sulfonyl group, m and p are different and represent 0 or 1, R1 and R2 may be the same or different from each other and represent a hydrogen atom, an unsubstituted or substituted alkyl group, an unsubstituted or substituted aryl group, an unsubstituted or substituted aralkyl group, an unsubstituted or substituted heterocyclic group containing nitrogen or an unsubstituted or substituted heterocyclic group containing oxygen, or R1 and R2, taken together with the nitrogen atom to which they are linked, may form an unsubstituted or substituted heterocyclic group, provided that when B is a sulfonyl group, R2 does not represent a hydrogen atom, n is an integer of 1 to 6, X represents a methylene group or an oxygen atom, E and Y may be the same or different from each other and represent a hydrogen atom, a halogen atom, an alkoxy group, or an alkyl group which may be substituted by a halogen atom    the dotted line shows the presence or absence of a bond,    when said dotted line shows the presence of a bond, Z represents a carbon atom, and when said dotted line shows the absence of a bond, Z represents CH or a nitrogen atom.

  式 (I) 的化合物或其盐或含有相同成分的药物 其中 A 和 B 代表羰基或磺酰基、 m 和 p 不同，代表 0 或 1、 R1 和 R2 可以相同或不同，代表氢原子、未取代或取代的烷基、未取代或取代的芳基、未取代或取代的芳烷基、未取代或取代的含氮杂环基团，或未取代或取代的含氧杂环基团，或 R1 和 R2 连同与其相连的氮原子可组成未取代或取代的杂环基团，但当 B 为磺酰基时，R2 不代表氢原子、 n 是 1 至 6 的整数、 X 代表亚甲基或氧原子、 E 和 Y 可以相同，也可以不同，代表氢原子、卤素原子、烷氧基或可被卤素原子取代的烷基 虚线表示键的存在或不存在、 当所述虚线表示存在键时，Z 代表碳原子；当所述虚线表示不存在键时，Z 代表 CH 或氮原子。
• WARDROP A. W. H.; SAINSBURY G. L.; HARRISON J. M.; INCH T. D., J. CHEM. SOC. PERKIN TRANS., PART 1, <JCPK-BH>, 1976, NO 12, 1279-1285
  作者：WARDROP A. W. H.、 SAINSBURY G. L.、 HARRISON J. M.、 INCH T. D.

  DOI：——

  日期：——
• Arylpiperidine and arylpiperazine derivatives and drugs containing the same
  申请人：SUNTORY LIMITED

  公开号：EP0757986B1

  公开（公告）日：2002-06-12
• US5723475A
  申请人：——

  公开号：US5723475A

  公开（公告）日：1998-03-03