N-(4-chlorobenzyl)hexanamide | 303092-22-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-chlorobenzyl)hexanamide
• 英文别名: N-4-chlorobenzylhexanamide；N-[(4-chlorophenyl)methyl]hexanamide
• CAS: 303092-22-0
• 化学式: C₁₃H₁₈ClNO
• mdl: MFCD01355972
• 分子量: 239.745
• InChiKey: FGHCZRALODBTOD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.461
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  己酰胺 、 对氯苄胺 在 Montmorillonite KSF 、 polymer-bound 4-(N-benzyl-N-methylamino)pyridine 、 氯化铪 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以82%的产率得到N-(4-chlorobenzyl)hexanamide
  参考文献：
  名称：

  Transamidation Catalyzed by a Recoverable and Reusable PolyDMAP‐Based Hafnium Chloride and Montmorillonite KSF

  摘要：

  In this article, we described the use of an easily available polymer-based hafnium chloride and montmorillonite KSF catalyst (HfCl4/KSF-polyDMAP) in transamidation under relatively mild conditions. This metal catalyst can be easily recovered and reused in this reaction to give the corresponding amides in good yields.

  DOI：

  10.1080/00397910500297180

文献信息

• Alpha helix mimetics and methods relating thereto
  申请人：PRISM BioLab Co., Ltd.

  公开号：US10017522B2

  公开（公告）日：2018-07-10

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a chemical library relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  本发明公开了由式（I）表示的α-螺旋拟态结构和化合物（其中通式和各符号的定义如说明书中所定义）、与之相关的化学库以及与之相关的方法。进一步公开了这些化合物在治疗医疗条件（例如癌症疾病、纤维化疾病）中的应用，以及包含该拟态化合物的药物组合物。
• Mesoporous Niobium Oxide Spheres as an Effective Catalyst for the Transamidation of Primary Amides with Amines
  作者：Subhash Chandra Ghosh、Cheng Chao Li、Hua Chun Zeng、Joyce S. Y. Ngiam、Abdul M. Seayad、Anqi Chen

  DOI：10.1002/adsc.201300717

  日期：2014.2.10

  AbstractMesoporous niobium oxide spheres (MNOS), conveniently prepared by a novel antisolvent precipitation approach, have been shown to be an effective catalyst for the transamidation of primary amides with amines. This novel transamidation can be efficiently carried out under solvent‐free conditions and is applicable to a wide range of primary amides and amines to provide N‐alkyl amides in good to excellent yields. The catalyst is highly stable and reusable. The application of this transamidation reaction has been demonstrated in the synthesis of antidepressant drug moclobemide and other drug‐like compounds.magnified image
• SELECTIVE INHIBITORS OF UNDIFFERENTIATED CELLS
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：US20180153830A1

  公开（公告）日：2018-06-07

  Uses of a compound of any of Formulas I-VI as a cytotoxic inhibitor of undifferentiated cells are disclosed herein, as well as pharmaceutical compositions comprising a compound of any of Formulas I-VI, and methods for identifying a lead candidate for inhibiting undifferentiated cells. Further disclosed are uses of an SCD-1 inhibitor as a cytotoxic inhibitor of undifferentiated cells.