N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(1-methyl-4-propionyloxy-2-propionylsulfanyl-but-1-enyl)-formamide | 1454-19-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(1-methyl-4-propionyloxy-2-propionylsulfanyl-but-1-enyl)-formamide
• 英文别名: N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(1-methyl-2-propionylmercapto-4-propionyloxy-but-1-en-t-yl)-formamide；N-(4-Amino-2-methyl-pyrimidin-5-ylmethyl)-N-(1-methyl-2-propionylmercapto-4-propionyloxy-but-1-en-t-yl)-formamid；O,S-Dipropionyl-thiamin
• CAS: 1454-19-9
• 化学式: C₁₈H₂₆N₄O₄S
• 分子量: 394.495
• InChiKey: IQZBIZCNXVORKL-QINSGFPZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.57
• 重原子数：
  27.0
• 可旋转键数：
  10.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  115.48
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  盐酸硫胺 、 丙酸酐 在 sodium hydroxide 、 水 、 sodium chloride 作用下， 生成 N-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-N-(1-methyl-4-propionyloxy-2-propionylsulfanyl-but-1-enyl)-formamide
  参考文献：
  名称：

  Nonsteroidal Anti-Inflammatory Therapy After Eccentric Exercise in Healthy Older Individuals

  摘要：

  Background. Aging is associated with greater susceptibility to muscle injury and soreness after exercise. Although elderly persons regularly consume nonsteroidal anti-inflammatory drugs (NSAIDs), it is not clear that NSAIDs alleviate muscle dysfunction and/or inflammation following injurious exercise.Methods. In this double-blind crossover study, 10 men and 5 women (aged 60 +/-2 years, mean SE) consumed naproxen sodium or placebo for 10 days after performing 64 unilateral eccentric (ECC knee extensions using 75% of the ECC 1-repetition maximum. Strength was measured before, 3 days after, and 10 days after each bout. Injury and soreness were assessed using magnetic resonance images of in. quadriceps femoris (QF) and a visual analog scale.Results. Three days after exercise, concentric strength loss was greater for placebo (-32 +/-9%) than NSAID (-6 +/-8%; p = .0064). Likewise, isometric strength declined less for NSAID than placebo (-12 +/-7% vs -24 +/-4%; p = .0213), and thigh soreness while rising from a chair was greater for placebo (p less than or equal to .0393) than NSAID (43 +/-7 mm vs 26 +/-7 mm). QF cross-sectional area (cm(2)) showing elevated T-2 was 27% and 35% greater (p less than or equal to .0096) for placebo on Days 3 and 10, respectively.Conclusions. Naproxen sodium attenuated muscle injury, strength loss, and soreness following ECC exercise in older individuals and may be beneficial during the early stages of increased physical activity.

  DOI：

  10.1093/gerona/56.8.m510

文献信息

• US2752348
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  公开号：——

  公开（公告）日：——
• DE929551
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