sodium 2-oxo-4-trifluoromethyl-2H-chromene-6-sulfonate | 732301-30-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: sodium 2-oxo-4-trifluoromethyl-2H-chromene-6-sulfonate
• 英文别名: sodium;2-oxo-4-(trifluoromethyl)chromene-6-sulfonate
• CAS: 732301-30-3
• 化学式: C₁₀H₄F₃O₅S*Na
• 分子量: 316.19
• InChiKey: NONIBNXQYOLRTN-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -1.28
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  91.9
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• [EN] ANDROGEN RECEPTOR ANTAGONISTS<br/>[FR] ANTAGONISTES DU RECEPTEUR DES ANDROGENES
  申请人：WARNER LAMBERT CO

  公开号：WO2004065379A1

  公开（公告）日：2004-08-05

  The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.

  本发明涉及一种新的6-磺酰胺基喹啉-2-酮和6-磺酰胺基-2-氧代色基衍生物类别，用作雄激素拮抗剂，并用于缓解与雄激素受体不适当激活相关的症状。
• [EN] 6-SULFONAMIDE QUINOLINE AND CHROMENE DERIVATIVE AS ANDROGEN RECEPTOR ANTAGONISTS<br/>[FR] DERIVES 6-SULFONAMIDE QUINOLEINIQUES ET CHROMENIQUES A TITRE D'ANTAGONISTES DES RECEPTEURS D'ANDROGENE
  申请人：WARNER LAMBERT CO

  公开号：WO2004083204A1

  公开（公告）日：2004-09-30

  The present invention is directed to 6-sulfonamide quinoline and chromene derivatives of the formula (I) with the definitions of M, R1, R2, A and B according to claim 1 and to their use as androgen antagonists.

  本发明涉及公式(I)的6-磺酰胺喹啉和色烯衍生物，其中M、R1、R2、A和B的定义如权利要求1所述，并将其用作雄激素拮抗剂。
• Androgen receptor antagonists
  申请人：Du Y. Daniel

  公开号：US20050085467A1

  公开（公告）日：2005-04-21

  The present invention is directed to a new class of 6-sulfonamido-quinolin-2-one and 6-sulfonamido-2-oxo-chromene derivatives to their use as androgen antagonists, and to relieve conditions associated with inappropriate activation of the androgen receptor.

  本发明涉及一种新的6-磺酰胺基喹啉-2-酮和6-磺酰胺基-2-氧代香豆素衍生物的类别，用作雄激素拮抗剂，并缓解与雄激素受体不适当激活相关的病症。
• Sulfonamide derivatives
  申请人：Du Y. Daniel

  公开号：US20050004367A1

  公开（公告）日：2005-01-06

  The present invention is directed to a new class of 6-sulfonamide quinoline and chromene derivative and to their use as androgen antagonists.

  本发明涉及一类新的6-磺酰胺喹啉和色烯衍生物，以及它们作为雄激素拮抗剂的用途。
• ANDROGEN RECEPTOR ANTAGONISTS
  申请人：Warner-Lambert Company LLC

  公开号：EP1587804A1

  公开（公告）日：2005-10-26