5-(3-phenyl-1-benzofuran-2-yl)-8-hydroxy-quinoline | 849222-34-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 5-(3-phenyl-1-benzofuran-2-yl)-8-hydroxy-quinoline
• 英文别名: 5-(3-phenyl-1-benzofuran-2-yl)quinolin-8-ol
• CAS: 849222-34-0
• 化学式: C₂₃H₁₅NO₂
• 分子量: 337.378
• InChiKey: DAYAIFQCBMRRAD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  26
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] SUBSTITUTED HETEROARYL BENZOFURAN ACIDS<br/>[FR] ACIDES HETEROARYL BENZOFURANE SUBSTITUES
  申请人：WYETH CORP

  公开号：WO2005030760A1

  公开（公告）日：2005-04-07

  The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them (I); or a pharmaceutically acceptable salt or ester form therof wherein: R, R1, R2 and R3 are, independently, hydrogen, alkyl, cycloalkyl, alkanoyl, halo, hydroxy, aryl, perfluoroalkyl, alkoxy, amino, alkylamino, dialkylamino, or perfluoroalkoxy; R4 is hydrogen, alkyl, perfluoroalkyl, alkenyl, alkynyl, arylalkenyl, arylalkynyl, aryl,-C(=O)R5, -C(=S)R5, -CH2R5, OR -CH(OH)R5; R5 is hydrogen, C1-C8 alkyl, C3-C8 cycloalkyl, perfluoroalkyl, aryl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, alkylaryl, alkenylaryl, or alkynylaryl; R6 is hydrogen, alkyl, aryl, or arylalkyl; x1, x2, x3, x4, x5, x6, x7, and x8 are, independently, carbon or nitrogen, wherein at least one of x1-x8 is a nitrogen atom; n is an integer from 0-6; and A is COOH or an acid mimic or a pharmaceutically acceptable salt thereof.

  本发明涉及一般地替代杂环芳基苯并呋喃酸及其使用方法（I）；或其药用可接受的盐或酯形式，其中：R、R1、R2和R3独立地是氢、烷基、环烷基、烷酰基、卤素、羟基、芳基、全氟烷基、烷氧基、氨基、烷基氨基、二烷基氨基或全氟烷氧基；R4是氢、烷基、全氟烷基、烯基、炔基、芳基烯基、芳基炔基、芳基、-C（=O）R5、-C（=S）R5、-CH2R5、OR或-CH（OH）R5；R5是氢、C1-C8烷基、C3-C8环烷基、全氟烷基、芳基、烯基、炔基、芳基烷基、芳基烯基、芳基炔基、烷基芳基、烯基芳基或炔基芳基；R6是氢、烷基、芳基或芳基烷基；x1、x2、x3、x4、x5、x6、x7和x8独立地是碳或氮，其中至少一个是氮原子；n是0-6之间的整数；A是COOH或酸模拟物或其药用可接受的盐。
• Substituted heteroaryl benzofuran acids
  申请人：Elokdah Mahmoud Hassan

  公开号：US20050119296A1

  公开（公告）日：2005-06-02

  The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them.

  本发明涉及替代杂环芳基苯并呋喃酸及其使用方法。
• SUBSTITUTED HETEROARYL BENZOFURAN ACIDS
  申请人：ELOKDAH Hassan Mahmoud

  公开号：US20090054484A1

  公开（公告）日：2009-02-26

  The present invention relates generally to substituted heteroaryl benzofuran acids and methods of using them.

  本发明通常涉及替代杂环芳基苯并呋喃酸及其使用方法。
• Process For Producing Epoxy Compound
  申请人：Tanaka Shinya

  公开号：US20090054669A1

  公开（公告）日：2009-02-26

  A process for producing an epoxy compound represented by the formula (3): wherein Ar 1 , Ar 2 , Ar 3 , R 1 , R 2 , R 3 , Q 1 and Q 2 are as defined below, which comprises reacting a dihydroxy compound represented by the formula (1): HO-Q 1 -Ar 1 —Ar 2 —Ar 3 -Q 1 -OH  (1) wherein Q 1 denotes a single bond, Ar 1 , Ar 2 and Ar 3 each denotes any one of divalent groups represented by the following formulas: and a compound represented by the formula (2): wherein R 1 , R 2 and R 3 denote hydrogen atom, Q 2 denotes a straight-chain alkylene group having 1 to 8 carbon atoms, and X denotes halogen atom, in the presence of at least one selected from the group consisting of an amine compound and an ammonium salt, and further reacting the obtained reaction mixture and an inorganic base by mixing.
• US7446201B2
  申请人：——

  公开号：US7446201B2

  公开（公告）日：2008-11-04