2-(6-(4-(9-(aminooxy)nonyl)-1H-1,2,3-triazol-1-yl)hexyl)benzene-1,4-diol | 1309932-23-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2-(6-(4-(9-(aminooxy)nonyl)-1H-1,2,3-triazol-1-yl)hexyl)benzene-1,4-diol
• CAS: 1309932-23-7
• 化学式: C₂₃H₃₈N₄O₃
• 分子量: 418.58
• InChiKey: HGCDNWJDCNNYCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.66
• 重原子数：
  30.0
• 可旋转键数：
  17.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  106.42
• 氢给体数：
  3.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  2-(6-(4-(9-(aminooxy)nonyl)-1H-1,2,3-triazol-1-yl)hexyl)benzene-1,4-diol 在 copper(II) sulfate 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以85%的产率得到
  参考文献：
  名称：

  Redox-Switchable Surface for Controlling Peptide Structure

  摘要：

  A general surface chemistry strategy is described for the development of a new switchable material. The method modulates a surface-immobilized-molecules structure by using two orthogonal "click" reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable. We demonstrate this strategy by developing a noninvasive, biocompatible, in situ surface chemistry that is able to modulate the affinity of a cell-adhesive peptide to cell integrin receptors to study dynamic cell adhesion and cell migration in real time and as a new hide-and-reveal strategy for application in new types of smart biofouling biomaterials.

  DOI：

  10.1021/ja203198y
• 作为产物：
  描述：

  10-十一炔醇 在 sodium L-ascorbate 、 碳酸氢钠 、 一水合肼 、 copper(II) sulfate 、 三乙胺 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 17.0h， 生成 2-(6-(4-(9-(aminooxy)nonyl)-1H-1,2,3-triazol-1-yl)hexyl)benzene-1,4-diol
  参考文献：
  名称：

  Redox-Switchable Surface for Controlling Peptide Structure

  摘要：

  A general surface chemistry strategy is described for the development of a new switchable material. The method modulates a surface-immobilized-molecules structure by using two orthogonal "click" reactions based on Huisgen cycloaddition and oxime chemistry, where the oxime linkage is redox active and switchable. We demonstrate this strategy by developing a noninvasive, biocompatible, in situ surface chemistry that is able to modulate the affinity of a cell-adhesive peptide to cell integrin receptors to study dynamic cell adhesion and cell migration in real time and as a new hide-and-reveal strategy for application in new types of smart biofouling biomaterials.

  DOI：

  10.1021/ja203198y