(+)-1-phenyl-3-diphenylphosphinoyl-1,2,3,6-tetrahydrophosphinine oxide | 1235834-98-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+)-1-phenyl-3-diphenylphosphinoyl-1,2,3,6-tetrahydrophosphinine oxide
• CAS: 1235834-98-6
• 化学式: C₂₄H₂₃ClO₂P₂
• 分子量: 440.846
• InChiKey: ISPBEUSRPYVSIS-QDPGVEIFSA-N

反应信息

• 作为产物：
  描述：

  Diphenylphosphine oxide 、 3-methyl-4-chloro-1,2-dihydro-1-phenylphosphorin 1-oxide 在 三甲基铝 作用下， 以 氯仿 、 水 为溶剂， 反应 20.0h， 生成 (1S,3S)-4-chloro-3-diphenylphosphoryl-5-methyl-1-phenyl-3,6-dihydro-2H-1lambda5-phosphinine 1-oxide 、 (+)-1-phenyl-3-diphenylphosphinoyl-1,2,3,6-tetrahydrophosphinine oxide
  参考文献：
  名称：

  Optically Active 6-Membered P-Heterocycles: 1-Phenyl-1,2-Dihydrophosphinine Oxide and 1-Phenyl-3-Diphenylphosphinoyl-1,2,3,6-Tetrahydrophosphinine Oxide

  摘要：

  The antipodes of racemic 1-phenyl-1,2-dihydrophosphinine oxides 1A and 1B were separated by resolution via formation of a diastereomeric complex using (-)-(2R,3R)-alpha,alpha,alpha',alpha'-tetraphenyl-1,4-dioxaspiro[4.5]decan-2,3-dimethanol (spiro-TADDOL) 2. The (+)-antipode of 1-phenyl-3-diphenylphosphinoyl-1,2,3,6-tetrahydrophosphinine oxide 3 was synthesized by the diastereoselective addition of diphenylphosphine oxide to the double-bond of (-)-1,2-dihydrophosphinine oxide 1A. The new chiral tetrahydrophosphinine oxide (+)-3 served, after double deoxygenation, as a novel P-chiral bidentate ligand in the corresponding platinum complex.

  DOI：

  10.2174/157017810790796345