2-(4-(1-acetyl-2-oxoindolin-3-ylideneamino)phenylsulfonyl)-4,5,6,7-tetrachloroisoindoline-1,3-dione | 1198306-56-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 2-(4-(1-acetyl-2-oxoindolin-3-ylideneamino)phenylsulfonyl)-4,5,6,7-tetrachloroisoindoline-1,3-dione
• 英文别名: 2-[4-[(1-acetyl-2-oxoindol-3-ylidene)amino]phenyl]sulfonyl-4,5,6,7-tetrachloroisoindole-1,3-dione
• CAS: 1198306-56-7
• 化学式: C₂₄H₁₁Cl₄N₃O₆S
• 分子量: 611.246
• InChiKey: WQWNWTMMZIJDHU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  38
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-[1-acetyl-2-oxoindolin-3-ylideneamino]benzenesulfanilamide 、 四氯苯二甲酸酐 在 溶剂黄146 作用下， 反应 8.0h， 以67%的产率得到2-(4-(1-acetyl-2-oxoindolin-3-ylideneamino)phenylsulfonyl)-4,5,6,7-tetrachloroisoindoline-1,3-dione
  参考文献：
  名称：

  Synthesis, antiviral and antimicrobial screening of some new 2-oxoindoline derivatives

  摘要：

  New 3-(2-(5-(aryldiazenyl)-4-methylthiazol-2-yl)hydrazono)indolin-2-ones were prepared by the reaction of isatin beta-thiosemicarbazone with different hydrazonoyl chlorides. Imide derivatives were prepared by the reaction of isatin hydrazone with various anhydrides, and a series of new sulfonimides was also synthesized. All new compounds were tested for their biological activities.

  DOI：

  10.1007/s10593-009-0301-z

文献信息

• Synthesis, antiviral and antimicrobial screening of some new 2-oxoindoline derivatives
  作者：Madiha Farghaly、Bakr F. Abdel-Wahab、Essam M. Ahmed

  DOI：10.1007/s10593-009-0301-z

  日期：2009.5

  New 3-(2-(5-(aryldiazenyl)-4-methylthiazol-2-yl)hydrazono)indolin-2-ones were prepared by the reaction of isatin beta-thiosemicarbazone with different hydrazonoyl chlorides. Imide derivatives were prepared by the reaction of isatin hydrazone with various anhydrides, and a series of new sulfonimides was also synthesized. All new compounds were tested for their biological activities.