2-(bis-diisopropylphosphino-methyl)-pyridine | 237763-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(bis-diisopropylphosphino-methyl)-pyridine
• 英文别名: 2-pyridylbis(diisopropylphosphino)methane；[di(propan-2-yl)phosphanyl-pyridin-2-ylmethyl]-di(propan-2-yl)phosphane
• CAS: 237763-64-3
• 化学式: C₁₈H₃₃NP₂
• 分子量: 325.414
• InChiKey: VXDGFVBLGZTLQI-UHFFFAOYSA-N

物化性质

• 沸点：
  397.1±42.0 °C(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tetrakis(acetonitrile)copper(I)tetrafluoroborate 、 2-(bis-diisopropylphosphino-methyl)-pyridine 以 四氢呋喃 、 二氯甲烷 为溶剂， 以15%的产率得到Cu2(η4-2-pyridyl(diisopropylphosphino)methane)2(BF4)2
  参考文献：
  名称：

  含吡啶基-异丙基膦混合配体的二钼（V），钯（II）和双铜（I）配合物的合成和结构研究

  摘要：

  摘要Mo2（μ-O2CCH3）4与2-吡啶基（二异丙基膦基）甲烷（NP）的反应提供了二钼（V）络合物Mo2（μ-O）2O2Cl2（η2-NP）2（1）。已分离出相关的2-吡啶基双（二异丙基膦基）甲烷配体（NP2）的配合物，即组成为PdBr1.09Cl0.91（η2-NP2）（2）和双铜（I）配合物的溴/氯混合配合物[ Cu 2（μ-η3 -NP 2）2]（BF 4）2（3）。通过X射线晶体学已经确定了1、2和3的结构。

  DOI：

  10.1016/s0020-1693(01)00721-6
• 作为产物：
  描述：

  氯二异丙基膦 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 13.0h， 生成 2-(bis-diisopropylphosphino-methyl)-pyridine
  参考文献：
  名称：

  Synthesis of Hemilabile P,N Ligands: ω-2-Pyridyl-n-alkylphosphines

  摘要：

  A series of P,N ligands of the general formula (2-py)-(CH2)(n)-PR2 (2-py: 2-pyridyl; R: i-Pr (n = 1, 4-7), Ph (n = 5-7)) 4a-g and 6a has been synthesized. Starting from 2-picoline (1), 2-(omega-chloroalkyl)pyridines 3a-d are prepared. The reactions of 3a-d with (i-Pr)(2)PLi and Ph2PLi, respectively, result in the title compounds 4a-g in up to 89% yield. Reaction of Cl-(CH2)(3)-P(i-Pr)(2) with 2-picolyllithium (2) is an alternative route to 4a. Additionally, P,P,N ligands 7a and 9 are synthesized by similar methods. All new compounds were fully characterized. The formation of cyclic pyridinium derivatives 5a and 5b from intramolecular SN reactions of 3a and 3b is discussed in detail.

  DOI：

  10.1007/pl00010260

文献信息

• Synthesis of Hemilabile P,N Ligands: ω-2-Pyridyl-n-alkylphosphines
  作者：Achim Jansen、Stephan Pitter

  DOI：10.1007/pl00010260

  日期：1999.6

  A series of P,N ligands of the general formula (2-py)-(CH2)(n)-PR2 (2-py: 2-pyridyl; R: i-Pr (n = 1, 4-7), Ph (n = 5-7)) 4a-g and 6a has been synthesized. Starting from 2-picoline (1), 2-(omega-chloroalkyl)pyridines 3a-d are prepared. The reactions of 3a-d with (i-Pr)(2)PLi and Ph2PLi, respectively, result in the title compounds 4a-g in up to 89% yield. Reaction of Cl-(CH2)(3)-P(i-Pr)(2) with 2-picolyllithium (2) is an alternative route to 4a. Additionally, P,P,N ligands 7a and 9 are synthesized by similar methods. All new compounds were fully characterized. The formation of cyclic pyridinium derivatives 5a and 5b from intramolecular SN reactions of 3a and 3b is discussed in detail.
• Synthesis and structural studies of dimolybdenum(V), palladium(II) and dicopper(I) complexes that contain mixed pyridyl-iso-propylphosphine ligands
  作者：Hui-Fang Lang、Phillip E Fanwick、Richard A Walton

  DOI：10.1016/s0020-1693(01)00721-6

  日期：2002.1

  Mo2(μ-O2CCH3)4 with 2-pyridyl(diisopropylphosphino)methane (NP) affords the dimolybdenum(V) complex Mo2(μ-O)2O2Cl2(η2-NP)2 (1). Complexes of the related 2-pyridylbis(diisopropylphosphino)methane ligand (NP2) have been isolated, namely, a mixed bromo/chloro complex of composition PdBr1.09Cl0.91(η2-NP2) (2) and the dicopper(I) complex [Cu2(μ-η3-NP2)2](BF4)2 (3). The structures of 1, 2 and 3 have been established

  摘要Mo2（μ-O2CCH3）4与2-吡啶基（二异丙基膦基）甲烷（NP）的反应提供了二钼（V）络合物Mo2（μ-O）2O2Cl2（η2-NP）2（1）。已分离出相关的2-吡啶基双（二异丙基膦基）甲烷配体（NP2）的配合物，即组成为PdBr1.09Cl0.91（η2-NP2）（2）和双铜（I）配合物的溴/氯混合配合物[ Cu 2（μ-η3 -NP 2）2]（BF 4）2（3）。通过X射线晶体学已经确定了1、2和3的结构。